Evidence map›Paper›PMID 41656825›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Stiff to Soft: A Protein-Based Buffer Layer for Improving the Long-Term Performance of Microneedle Sensors.

Lihao Guo, Youbin Zheng, Shuxiang Xu, Bingbing Feng, Kan Wang, Rou Huang, Gandong Zhou, Chutong Liu, Rawan Omar, Danyao Qu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lihao GuoPrecision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Youbin ZhengDepartment of Medicine, Laboratory for Life Sciences and Technology (LiST), Faculty of Medicine and Dentistry, Danube Private University, Krems, Austria.ORCID https://orcid.org/0000-0003-3905-8552
Shuxiang XuPrecision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bingbing FengPrecision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kan WangSchool of Automation and Intelligent Sensing, Shanghai Jiao Tong University, Shanghai, China.
Rou HuangSchool of Advanced Materials and Nanotechnology, Xidian University, Xi'an, China.
Gandong ZhouPrecision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chutong LiuPrecision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Rawan OmarDepartment of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, Israel.
Danyao QuDepartment of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, Israel.
Jinbao LiDepartment of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Min ZhangSchool of Chemistry and Molecular Engineeringin Situ Devices Research Center, East China Normal University, Shanghai, China.
Weiwei WuSchool of Information Mechanics and Sensing Engineering, Xidian University, Xi'an, China.
Guangjian ZhangDepartment of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.
Lina HuangPrecision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hossam HaickDepartment of Medicine, Laboratory for Life Sciences and Technology (LiST), Faculty of Medicine and Dentistry, Danube Private University, Krems, Austria.ORCID https://orcid.org/0000-0002-2370-4073
Miaomiao YuanPrecision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-2477-9066

Funding

European Union's Horizon Europe Research and Innovation programme 101096473Fundamental Research Funds for the Central Universities YG2025QNB08(MMY)National Natural Science Foundation of China 82303309(SXX)National Natural Science Foundation of China 82470107(GJZ)National Natural Science Foundation of China 82471253(LNH)National Natural Science Foundation of China 82572445 (MMY)Natural Science Foundation of Shanghai Municipality 23ZR1450800(LNH)Seed Project for Research and Translation of New Medical Technologies, Shanghai Municipal Health Commission 2024ZZ2015(MMY)VOLABIOS 101156162
6 · The paper itself

Abstract

Long-term monitoring of electrolyte dynamics is essential for managing chronic diseases. Conventional diagnostic tests are steadily evolving toward greater convenience, personalization, and accuracy, while wearable microneedle sensors offer a compelling alternative. However, their long-term biocompatibility is hampered by the mechanical stiffness required to penetrate the skin. Here we report a crosslinking-recombination bovine serum albumin (CR-BSA) coating that undergoes a unique stiff-to-soft transition, reconciling insertion capability with tissue compatibility. For Na

Indexed as

Biosensing TechniquesMechanical PhenomenaNeedlesSerum Albumin, BovineAnimalsBuffersCattleMicroneedle Drug DeliverySodiumBuffersSerum Albumin, BovineSodiumbiopolymerbiosecurityfibrotic lesionmicroneedlesensor

Identifiers

PMID41656825
PMCPMC12983446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.