ReviewZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025
[Mechanistic research progress on radiotherapy resistance of cancer stem cells].
Review in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy is an important treatment modality for tumors and is involved in the treatment course of more than 50% of cancer patients. However, resistance to ionizing radiation results in suboptimal radiotherapy efficacy and contributes to tumor recurrence and metastasis at later stages. With the increasing understanding of tumor pathogenesis, cancer stem cell (CSC), characterized by self-renewal capacity and differentiation potential, have attracted growing attention and play key roles in radiotherapy resistance, tumor progression, metastasis, immune evasion, and other processes. Mechanisms including the tumor microenvironment, DNA damage repair, and epithelial-mesenchymal transition (EMT) are critical drivers of CSC-mediated radiotherapy resistance. Reviewing the key pathways involved and identifying CSC-specific therapeutic targets may provide new insights for developing more efficient and less toxic radiotherapy strategies.
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Registered trials
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