ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025
[Correlation between
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
objectivesPreeclampsia (PE) is a clinical syndrome characterized by new-onset hypertension and proteinuria after 20 weeks of gestation, seriously affecting the short- and long-term health of both mothers and infants. The etiology and pathogenesis of PE remain incompletely understood. The Notch signaling pathway plays an important role in early upstream processes of PE, including trophoblast invasion and placental angiogenesis. Jagged canonical Notch ligand 1 (
methodsA hospital-based case-control study was conducted, including 117 pathologically confirmed PE patients recruited from March to December 2021 as the case group, and 266 age-matched non-PE women recruited during the same period as the control group. Demographic characteristics, reproductive history, personal disease history, family history, and pregnancy lifestyle factors were collected using standardized questionnaires. Peripheral venous blood samples were obtained for genotyping 12
resultsEight of the 12
conclusionsThe G allele at rs73604319 in the JAG1 gene may be associated with reduced PE risk. The CTCG and CCCG haplotypes constructed from rs1051412, rs73611723, rs7264849, and rs73604319 loci may be associated with reduced PE risk. A potential multiplicative interaction between rs73604319 and rs73611723 may influence PE risk. Bioinformatics suggests that rs73604319 and rs73611723 reside in open chromatin regions and may be related to promoter functions regulating
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.