Evidence map›Paper›PMID 41656808›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025

[Heterogeneity in the regulation of cellular stress responses by

Chenchen Yu, Weiqian Zeng, Piyanat Meekrathok, Yue Bu, Junling Wang, Jian Qiu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenchen YuKey Laboratory of Molecular Precision Medicine of Hunan Province, Xiangya Hospital, Central South University, Changsha 410008. yu_cc@outlook.com.
Weiqian ZengKey Laboratory of Molecular Precision Medicine of Hunan Province, Xiangya Hospital, Central South University, Changsha 410008. 4011699@csu.edu.cn.
Piyanat MeekrathokKey Laboratory of Molecular Precision Medicine of Hunan Province, Xiangya Hospital, Central South University, Changsha 410008.
Yue BuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Junling WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Jian QiuKey Laboratory of Molecular Precision Medicine of Hunan Province, Xiangya Hospital, Central South University, Changsha 410008. qiujian@sklmg.edu.cn.

Funding

the Project of Department of Science and Technology of Hunan Province 2019RS1010
6 · The paper itself

Abstract

objectivesAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the selective death of motor neurons, exhibiting marked clinical heterogeneity and lacking effective treatment. The etiology and pathogenic mechanisms remain incompletely understood. The

methodsMultiple sequence alignment of FUS protein homologs from 12 species was performed using an online tool from the National Center for Biotechnology Information (NCBI) to determine the evolutionary conservation of residues R514 and P525. The three-dimensional (3D) structure of the nuclear transport receptor-FUS complex [Protein Data Bank (PDB) ID: 5YVG] was analyzed and visualized using PyMOL. Structure of FUS mutants were generated using the mutation wizard tool in PyMOL by selecting the target conformational isomer and executing the mutation workflow. Tet-on inducible expression cell models for FUS wild-type (WT) and mutant FUS (

resultsSequence alignment revealed that R514 and P525 are highly conserved across FUS homologs from 12 species. Structural analysis indicated that the

conclusionsDistinct pathogenic NLS mutations of FUS differentially regulate cellular stress responses through different mechanisms, contributing to ALS initiation and progression. Among these,

Indexed as

Amyotrophic Lateral SclerosisMutationRNA-Binding Protein FUSStress, PhysiologicalHumansNuclear Localization SignalsFUS protein, humanNuclear Localization SignalsRNA-Binding Protein FUSamyotrophic lateral sclerosisfused in sarcoma geneintegrated stress responsestress granulesstress response

Identifiers

PMID41656808
PMCPMC12949858

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.