Evidence map›Paper›PMID 41656807›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025

Mechanisms of gypenosides in type 2 diabetes mellitus via regulation of m6A methylase METTL3/14 and demethylase FTO.

Jiayi Li, Shaoqian Zhang, Renwei Tian, Hebei Tai, Yating Zhang, Mingyi Hu, Guangbin Gong, Jianfei Sun, Ning Wu

Abstract read
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In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jiayi LiLaboratory of Chemistry and Biochemistry, Guizhou Medical University, Guiyang 550004, China. 1842443937@qq.com.
Shaoqian ZhangLaboratory of Chemistry and Biochemistry, Guizhou Medical University, Guiyang 550004, China. 2246454794@qq.com.
Renwei TianLaboratory of Chemistry and Biochemistry, Guizhou Medical University, Guiyang 550004, China.
Hebei TaiLaboratory of Chemistry and Biochemistry, Guizhou Medical University, Guiyang 550004, China.
Yating ZhangLaboratory of Chemistry and Biochemistry, Guizhou Medical University, Guiyang 550004, China.
Mingyi HuLaboratory of Chemistry and Biochemistry, Guizhou Medical University, Guiyang 550004, China.
Guangbin GongLaboratory of Chemistry and Biochemistry, Guizhou Medical University, Guiyang 550004, China.
Jianfei SunLaboratory of Chemistry and Biochemistry, Guizhou Medical University, Guiyang 550004, China. tyczyc@163.com.
Ning WuLaboratory of Chemistry and Biochemistry, Guizhou Medical University, Guiyang 550004, China. wuning@gmc.edu.cn.

Funding

College Students' Innovative Entrepreneurial Training Plan Program of Guizhou Province, China S202210660105 and S202310660055This is an open access article under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International CC BY-NC-ND 4.0 and //creativecommons.org/licenses/by-nc-nd/4.0/
6 · The paper itself

Abstract

objectivesType 2 diabetes mellitus (T2DM) is characterized by insufficient insulin secretion and insulin resistance. Gypenosides (GPs) are the major bioactive saponins extracted from Gynostemma pentaphyllum. Previous studies suggest that GPs have beneficial effects on T2DM, but the underlying mechanisms remain unclear. This study aims to investigate whether GPs exert therapeutic effects by influencing RNA N

methodsExpression levels and methylation changes of

resultsBioinformatic analyses showed downregulation of

conclusionsGPs can effectively improve glucose-metabolism disorders, reduce inflammation, and protect pancreatic tissue in T2DM rats. The mechanisms may be associated with

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTODiabetes Mellitus, Type 2MethyltransferasesAdenosineAnimalsDiabetes Mellitus, ExperimentalGynostemmaHumansInsulin ResistanceMalePlant ExtractsProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyRNA MethylationSignal TransductionAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOgypenosideMethyltransferasesMETTL14 protein, humanMETTL3 protein, humanN-methyladenosinePlant ExtractsProto-Oncogene Proteins c-aktgypenosidesm6A methylation modificationMETTL14METTL3obesity-associated proteinPI3K/AKT signaling pathwayRNA modificationtype 2 diabetes mellitus

Identifiers

PMID41656807
PMCPMC12949872

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.