Evidence map›Paper›PMID 41656634›Full record

ReviewJournal of stroke2026

Endovascular Therapy for Extensive Infarction in Acute Ischemic Stroke.

Ashutosh P Jadhav, Gisele Sampaio Silva, Xinyi Leng, Claus Z Simonsen, Alejandro A Rabinstein, David S Liebeskind

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ashutosh P JadhavDepartment of Neurology and Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
Gisele Sampaio SilvaUniversidade Federal de São and Hospital Israelita Albert Einstein, São Paulo, Brazil.
Xinyi LengDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Claus Z SimonsenDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Alejandro A RabinsteinDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
David S LiebeskindDepartment of Neurology, Neurovascular Imaging Research Core, University of California, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute ischemic stroke is the leading cause of permanent disability and second leading cause of death worldwide. Over the past 10 years, mechanical thrombectomy has become a powerful technique for improving outcomes after large-vessel occlusion in patients with a small baseline infarct. Reperfusion in patients with extensive infarction has historically been considered futile or harmful. However, a recent series of trials showed that endovascular therapy benefits patients who present with extensive baseline infarction. These new data represent a paradigm shift in the approach to stroke therapy, leading to an expansion of indications. Therefore, more patients will benefit from mechanical thrombectomy. Furthermore, these data challenge current definitions of infarct and ischemia as seen on imaging. The data suggest a new era of reperfusion therapy that focuses on optimizing patient-specific approaches and developing adjunctive neuroprotectants and neurorestorative therapies.

Indexed as

Ischemic strokeLarge coreLarge vessel occlusionPrecision medicineThrombectomy

Identifiers

PMID41656634
PMCPMC12883880

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.