Evidence map›Paper›PMID 41656611›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

A linear-no-threshold association between carotid intima-media thickness and cognitive function: The mediating role of cerebrovascular disease.

Wenqiang Zhang, Lingli Qiu, Yunjie Liu, Yutong Wang, Mingshuang Tang, Lin Chen, Xia Jiang

Abstract read
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In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenqiang ZhangJiangxi Provincial Key Laboratory of Molecular Medicine, Jiangxi Medical College, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.ORCID 0000-0002-0317-3914
Lingli QiuDepartment of Epidemiology and Biostatistics, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Yunjie LiuDepartment of Epidemiology and Biostatistics, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Yutong WangDepartment of Epidemiology and Biostatistics, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Mingshuang TangDepartment of Epidemiology and Biostatistics, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Lin ChenDepartment of Epidemiology and Biostatistics, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Xia JiangDepartment of Epidemiology and Biostatistics, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carotid intima-media thickness (cIMT), a noninvasive marker of subclinical atherosclerosis beginning in childhood, has been linked to cognitive decline in adulthood. However, the nature and shape of this association remain unclear. We investigated linear and nonlinear associations between cIMT and cognitive function using observational and Mendelian randomization (MR) analyses. Observational and one-sample MR analyses were conducted in UK Biobank participants (

Indexed as

Carotid Intima-Media ThicknessCerebrovascular DisordersCognitionAgedFemaleHumansMaleMendelian Randomization AnalysisMiddle AgedCarotid intima–media thicknesscausalitycognitive functiondose–response relationshipMendelian randomization

Identifiers

PMID41656611
PMCPMC12885970

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.