Evidence map›Paper›PMID 41656502›Full record

ArticleArchiv der Pharmazie2026

Benzoxaboroles Are Inhibitors of the η-Class Carbonic Anhydrase From Plasmodium falciparum.

Alessandro Bonardi, Sharon Wein, Muhamad Mustafa, Rachel Cerdan, Viviana de Luca, Clemente Capasso, Paola Gratteri, Claudiu T Supuran, Alessio Nocentini, Jean-Yves Winum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archiv der Pharmazie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessandro BonardiNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Firenze, Italy.ORCID https://orcid.org/0000-0002-5520-740X
Sharon WeinLPHI, Univ Montpellier, CNRS, INSERM, Campus Triolet, Place Eugène Bataillon, Montpellier, France.ORCID https://orcid.org/0000-0001-5662-2413
Muhamad MustafaIBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France.ORCID https://orcid.org/0000-0002-1384-7556
Rachel CerdanLPHI, Univ Montpellier, CNRS, INSERM, Campus Triolet, Place Eugène Bataillon, Montpellier, France.ORCID https://orcid.org/0000-0001-8214-8006
Viviana de LucaDepartment of Biology, Agriculture and Food Sciences, National Research Council (CNR), Institute of Biosciences and Bioresources, Naples, Italy.ORCID https://orcid.org/0000-0003-3406-833X
Clemente CapassoDepartment of Biology, Agriculture and Food Sciences, National Research Council (CNR), Institute of Biosciences and Bioresources, Naples, Italy.ORCID https://orcid.org/0000-0003-3314-2411
Paola GratteriNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Sesto Fiorentino, Firenze, Italy.ORCID https://orcid.org/0000-0002-9137-2509
Claudiu T SupuranNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Firenze, Italy.ORCID https://orcid.org/0000-0003-4262-0323
Alessio NocentiniNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Firenze, Italy.ORCID https://orcid.org/0000-0003-3342-702X
Jean-Yves WinumIBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France.ORCID https://orcid.org/0000-0003-3197-3414

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria remains a major global health burden, compounded by increasing resistance to current therapies. Plasmodium falciparum carbonic anhydrase (PfaCA), a η-class metalloenzyme essential for the parasite metabolism and survival, has recently emerged as a promising antimalarial target. In this study, benzoxaborole 4 and its 6-substituted triazolyl derivatives (5-18) were evaluated for PfaCA inhibition and in vitro antiplasmodial activity against the P. falciparum 3D7 strain. Compounds 13 and 14 emerged as the most potent inhibitors (K

Indexed as

AntimalarialsBoron CompoundsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesPlasmodium falciparumDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureParasitic Sensitivity TestsStructure-Activity RelationshipAntimalarialsBoron CompoundsCarbonic Anhydrase InhibitorsCarbonic Anhydrasesbenzoxaborolecarbonic anhydraseinhibitormalariamolecular dockingPlasmodium falciparum

Identifiers

PMID41656502
PMCPMC12883697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.