Evidence map›Paper›PMID 41656499›Full record

ArticleScandinavian journal of immunology2026

Role of CXCR3 and CXCR6 on Circulating T Cells in Patients With Parkinson's Disease.

Yufeng Zhang, Zhuangzhuang Ren, Shuangshuang Jia, Jinming Han, Xiaoling Zhong, Bo Fu, Haoran Wang, Shiping Xu, Tingting Li, Feng Qiu

Abstract read
In one paragraph

Article in Scandinavian journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yufeng ZhangMedical School of Chinese PLA, Beijing, China.ORCID https://orcid.org/0009-0001-4130-9122
Zhuangzhuang RenDepartment of Neurology, the Eighth Medical Center, Chinese PLA General Hospital, Beijing, China.
Shuangshuang JiaDepartment of Neurology, the Eighth Medical Center, Chinese PLA General Hospital, Beijing, China.
Jinming HanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-6084-3275
Xiaoling ZhongDepartment of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0001-9151-7264
Bo FuState Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
Haoran WangState Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
Shiping XuDepartment of Gastroenterology, the Second Medical Center, Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0009-0006-3648-8943
Tingting LiState Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
Feng QiuDepartment of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0001-6931-1219

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune dysregulation is involved in Parkinson's disease (PD), but the roles of C-X-C motif chemokine receptor 3 (CXCR3)/chemokine receptor 6 (CXCR6) on T cells and their correlation with peripheral inflammation remain unclear. This study investigated their expression on peripheral blood T cells and correlation with inflammation in PD. A total of 36 PD patients and 26 healthy controls were enrolled; their clinical information and laboratory test results (including the systemic immunoinflammatory index [SII], neutrophil-to-lymphocyte ratio [NLR], monocyte-to-lymphocyte ratio [MLR], platelet-to-lymphocyte ratio [PLR], monocyte-to-high-density lipoprotein ratio [MHR], and erythrocyte distribution width over platelets ratio [RPR]) were recorded. Meanwhile, a multicolour flow cytometry protocol using six cell surface antibodies (CD3, CD4, CD8, CD45RO, CXCR3, and CXCR6) was applied. The results showed that CD8

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesParkinson DiseaseReceptors, CXCR3Receptors, CXCR6AgedFemaleHumansMaleMiddle AgedCXCR3 protein, humanCXCR6 protein, humanReceptors, CXCR3Receptors, CXCR6cellular immunityCXCR3CXCR6Parkinson's disease (PD)peripheral inflammation

Identifiers

PMID41656499
PMCPMC12883700

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.