ReviewReviews in medical virology2026
Advances in Rapid Nucleic Acid Diagnostics for Hepatitis B and C Viruses: A Comprehensive Review.
Review in Reviews in medical virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Chronic viral hepatitis, predominantly caused by HBV and HCV infections, remains a major global health burden and a leading cause of cirrhosis, hepatocellular carcinoma (HCC), and liver-related mortality. Achieving the World Health Organisation (WHO) target of diagnosing 90% of HBV and HCV infections by 2030 necessitates a fundamental transition from centralised laboratory-based testing towards rapid, accessible, and decentralised diagnostic solutions. This review provides a comprehensive and critical assessment of the current diagnostic landscape for viral hepatitis, spanning established commercial assays and emerging nucleic acid testing (NAT) technologies. We systematically examine recent advances in biosensor-enabled diagnostics, with particular emphasis on the integration of isothermal amplification and CRISPR-based molecular recognition into electrochemical and field-effect transistor (FET) platforms. These electronic sensing technologies enable label-free signal transduction, scalable miniaturisation, and seamless integration with point-of-care (POC) workflows, thereby addressing key limitations of conventional diagnostic pipelines. In addition, we discuss persistent challenges in sample preparation, signal amplification, and system integration, and highlight strategies that couple biochemical amplification with solid-state electronics to streamline diagnostic workflows. By synthesising the state of the art and identifying critical technological bottlenecks, this review describes the technological progression of next-generation diagnostic platforms required to accelerate the global elimination of viral hepatitis and to improve patient outcomes through earlier and more equitable access to diagnosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.