Evidence map›Paper›PMID 41656465›Full record

ReviewBulletin of experimental biology and medicine2025

Antiviral Activity of Plant-Based Preparations against SARS-CoV-2 and Herpes Simplex Virus Type 2 In Vitro: A Review of Experimental Findings.

E I Kazachinskaia, L N Zibareva, Y V Kononova, A M Shestopalov, M I Voevoda, A A Chepurnov

Abstract readReview
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In one paragraph

Review in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E I KazachinskaiaFederal Research Center of Fundamental and Translational Medicine, Research Institute of Virology, Novosibirsk, Russia.
L N ZibarevaTomsk State University, Tomsk, Russia.
Y V KononovaFederal Research Center of Fundamental and Translational Medicine, Research Institute of Virology, Novosibirsk, Russia.
A M ShestopalovFederal Research Center of Fundamental and Translational Medicine, Research Institute of Virology, Novosibirsk, Russia.
M I VoevodaFederal Research Center of Fundamental and Translational Medicine, Research Institute of Virology, Novosibirsk, Russia.
A A ChepurnovFederal Research Center of Fundamental and Translational Medicine, Research Institute of Virology, Novosibirsk, Russia. alexa.che.purnov@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We reviewed published data on the efficacy of plant-derived preparations, including the authors' original in vitro findings on the antiviral activity of aqueous and dry ethanol extracts against the RNA virus SARS-CoV-2 and the DNA virus herpes simplex virus type 2 (HSV-2). The study evaluates the activity of an aqueous extract prepared from fermented leaves of Epilobium angustifolium L., as well as dry ethanol extracts obtained from clove spice (Syzygium aromaticum L.), black and green tea (Camellia sinensis L.), leaves of Rhaponticum carthamoides, the basidiomycete fungus chaga (Inonotus obliquus (Ach. ex Pers.) Pil.), and four lichen species: Cetraria islandica L., Usnea L., Pseudevernia furfuracea L., and Cladonia stellaris Opiz. HPLC analysis of several dry ethanol extracts suggests that their antiviral activity may be attributed to polyphenolic compounds and ecdysteroids. These findings may serve as a basis both for the identification of individual bioactive plant-derived compounds and for the development of cost-effective therapeutic or prophylactic agents against COVID-19 and for reducing the recurrence rate of chronic genital herpes.

Indexed as

Antiviral AgentsHerpesvirus 2, HumanPlant ExtractsSARS-CoV-2AnimalsCOVID-19 Drug TreatmentHumansPlant LeavesAntiviral AgentsPlant Extractsantiviral activityHSV-2plant raw materialsSARS-CoV-2

Identifiers

PMID41656465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.