Evidence map›Paper›PMID 41656443›Full record

ReviewCurrent pain and headache reports2026

Integrating Pain Prehabilitation into Surgical Pathways: Current Modalities, Outcomes, and Research Gaps.

Eric A Sosa, Anabel Henick, Dhanesh D Binda, Crystal Joseph, Stanley Kim, Dave Mathew, Singh Nair, Jinu Kim, David C Adams, Karina Gritsenko and 5 more

Abstract readReview
In one paragraph

Review in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Eric A SosaDepartment of Anesthesiology, Montefiore Medical Center, 111 E. 210Th Street, Bronx, NY, 10467, USA.ORCID http://orcid.org/0000-0001-5965-3477
Anabel HenickDepartment of Anesthesiology, Montefiore Medical Center, 111 E. 210Th Street, Bronx, NY, 10467, USA.
Dhanesh D BindaDepartment of Anesthesiology, Montefiore Medical Center, 111 E. 210Th Street, Bronx, NY, 10467, USA.ORCID http://orcid.org/0000-0002-5490-2013
Crystal JosephDepartment of Anesthesia, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2329-1448
Stanley KimDepartment of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dave MathewRutgers Health/Community Medical Center, Toms River, NJ, USA.ORCID http://orcid.org/0000-0002-1481-457X
Singh NairDepartment of Anesthesiology, Montefiore Medical Center, 111 E. 210Th Street, Bronx, NY, 10467, USA.ORCID http://orcid.org/0000-0001-7634-8239
Jinu KimDepartment of Anesthesiology, Montefiore Medical Center, 111 E. 210Th Street, Bronx, NY, 10467, USA.
David C AdamsDepartment of Anesthesia, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-6845-8734
Karina GritsenkoDepartment of Anesthesiology, Montefiore Medical Center, 111 E. 210Th Street, Bronx, NY, 10467, USA.ORCID http://orcid.org/0000-0002-8871-6374
Alan D KayeDepartment of Anesthesia, Louisiana State University School of Medicine, Shreveport, LA, USA.ORCID http://orcid.org/0000-0003-2464-0187
Ugur YenerDepartment of Rehabilitation Medicine, Montefiore Medical Center, Bronx, NY, USA.
Hatice Begum CiftciDepartment of Rehabilitation Medicine, Montefiore Medical Center, Bronx, NY, USA.
Sayed E WaheziDepartment of Rehabilitation Medicine, Montefiore Medical Center, Bronx, NY, USA.
Naum ShaparinDepartment of Anesthesiology, Montefiore Medical Center, 111 E. 210Th Street, Bronx, NY, 10467, USA. nshapari@montefiore.org.ORCID http://orcid.org/0000-0003-1060-429X

Funding

Medical Scientist Training ProgramT32GM149364 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Myles H. Akabas · 2023 to 2026
$7.5M
Defining the gene regulatory roles of non-coding variants in the pathogenesis of autismF31MH131380 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOSA, ERIC ALEXANDER · 2022 to 2025
$213k
Albert Einstein College of Medicine Medical Scientist Training Program (MSTP) grant T32-GM149364NIGMS NIH HHS T32 GM149364NIMH NIH HHS F31 MH131380Ruth L. Kirschstein Predoctoral Individual National Research Service F31-Award 1F31MH131380-03
6 · The paper itself

Abstract

purpose of reviewPrehabilitation constitutes a multidisciplinary strategy aimed at improving physiological and psychological readiness prior to surgery. Within pain medicine, prehabilitation provides an opportunity to address modifiable pain-related and functional risk factors prior to major procedures. This narrative review synthesizes contemporary evidence on prehabilitation modalities, their impact on surgical and pain-relevant outcomes, and persistent knowledge gaps limiting integration into perioperative pain pathways. RECENT

findingsA targeted PubMed search was performed on June 25, 2025. Supplementary exploratory searches in Web of Science and Scopus did not identify unique eligible studies beyond those already captured in PubMed. After excluding non-original reports and studies lacking outcome data, 153 clinical studies were included. The most frequently represented surgical specialties were general surgery (43%), orthopedic surgery (21%), and cardiothoracic surgery (18%). Single-modality prehabilitation was reported in 43% of studies, whereas multimodal approaches varied by specialty, occurring in 36% of general surgery studies and 13% of cardiothoracic surgery studies. Five principal prehabilitation modalities were identified: exercise, nutrition, psychological intervention, substance cessation, and medical optimization. Exercise-based interventions were the most common, incorporated in 84.7% of studies, followed by nutritional interventions in 29.5%. Overall, 82% reported improvements in at least one postoperative or functional outcome, although pain-specific endpoints were inconsistently reported. Prehabilitation appears beneficial across surgical specialties; however, pain outcomes remain underreported, and multimodal programs remain limited. Future work should standardize pain endpoints and evaluate multimodal interventions to guide integration of prehabilitation into perioperative pain management pathways.

Indexed as

Pain ManagementPostoperative PainPreoperative CarePreoperative ExerciseHumansAnesthesiologyEnhanced recoveryPain managementPerioperative medicinePerioperative painPrehabilitationSurgery

Identifiers

PMID41656443
PMCPMC12883514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.