Evidence map›Paper›PMID 41656384›Full record

ArticleAbdominal radiology (New York)2026

Loss of both diffusion restriction and arterial enhancement can predict complete pathological response following Y-90 selective internal radiation therapy for hepatocellular carcinoma.

Kah Heng Alexander Lim, Matthew Joel Clifford, William Ormiston, Tze Sheng Khor, Khanh Quoc Steven Ngo, Alistair Rowcroft, Lingjun Mou, Luc Delriviere, Michael Wallace, Mayank Bhandari and 2 more

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Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Kah Heng Alexander LimSir Charles Gairdner Hospital, Nedlands, Australia.
Matthew Joel CliffordSir Charles Gairdner Hospital, Nedlands, Australia.
William OrmistonSir Charles Gairdner Hospital, Nedlands, Australia.
Tze Sheng KhorPathwest Laboratory Medicine, Nedlands, Australia.
Khanh Quoc Steven NgoSir Charles Gairdner Hospital, Nedlands, Australia.
Alistair RowcroftFiona Stanley Hospital, Perth, Australia.
Lingjun MouSir Charles Gairdner Hospital, Nedlands, Australia. lingjun.mou@gmail.com.
Luc DelriviereSir Charles Gairdner Hospital, Nedlands, Australia.
Michael WallaceSir Charles Gairdner Hospital, Nedlands, Australia.
Mayank BhandariFiona Stanley Hospital, Perth, Australia.
Mohammad BallalUniversity of Western Australia, Perth, Australia.
Jonathan TibballsSir Charles Gairdner Hospital, Nedlands, Australia. Jonathan.Tibballs@health.wa.gov.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the association of diffusion restriction on diffusion weighted MRI (DWI) with complete pathological necrosis (CPN) in hepatocellular carcinoma (HCC) following selective internal radiation therapy with Yttrium-90 resin microspheres (SIRT).

methodsA retrospective cohort study of patients undergoing resection or transplantation for HCC following SIRT was performed. Imaging pre- and post-SIRT was assessed for response to treatment via mRECIST and for the presence of diffusion restriction on DWI. Histological specimens were assessed for complete pathological necrosis (CPN).

resultsTwenty-nine tumours were included from 25 patients; mRECIST complete response (CR) demonstrated moderate reliability (sensitivity 0.92, specificity 0.68) for predicting CPN. Twelve tumours did not have diffusion restriction on pretreatment DWI; following their exclusion, loss of diffusion restriction demonstrated a weak agreement (sensitivity 0.85, specificity 0.80, Cohen's Kappa 0.197) for prediction of CPN. The combination of mRECIST CR and loss of diffusion restriction was associated with CPN in 100% (6/6) cases; whilst persistent abnormal diffusion restriction despite mRECIST CR was associated with residual disease in 75% (3/4) cases.

conclusionThe combination of mRECIST CR when combined with loss of diffusion restriction appears to predict CPN post SIRT; persistent diffusion restriction despite the findings of mRECIST CR appears to correlate with residual disease.

Indexed as

Carcinoma, HepatocellularDiffusion Magnetic Resonance ImagingLiver NeoplasmsYttrium RadioisotopesAgedContrast MediaFemaleHumansMaleMiddle AgedPathologic Complete ResponsePredictive Value of TestsRadioembolization, TherapeuticReproducibility of ResultsRetrospective StudiesSensitivity and SpecificityContrast MediaYttrium-90Yttrium RadioisotopesDiffusion restrictionDiffusion weighted imaging (DWI)Hepatocellular carcinoma (HCC)mRECISTPathological responseSelective internal radiation therapy (SIRT)

Identifiers

PMID41656384
PMCPMC13388373

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