Trial reportJournal of neurology2026
Construct validity of instrumented gait assessments in hospital and daily life mobility in patients with Parkinson's disease and atypical Parkinson's syndromes: an exploratory study.
Trial report in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The future digital outpatient clinic for movement disorders: from technological innovation to ethical and systemic implementation-a position paper.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
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Authors and funding
17 authors.
Funding
Abstract
BACKGROUND AND
aimParkinsonian disorders are hallmarked by gait and balance impairments. Atypical parkinsonian disorders (APD) develop postural instability with falls and gait disorders early on. Sensor-based gait recordings provide objective data in hospital and everyday life, improving mobility assessment accuracy. However, the impact of duration and distance of instrumented assessments on construct validity remains unclear. This exploratory study aims to evaluate the construct validity of gait assessments compared with clinical, functional, and patient-reported scores.
methodsThe multi-centered Mobility_APP study recruited 43 PD and 49 APD patients. Among others, the Berg Balance Scale (BBS) and the postural instability and gait difficulty score (PIGD) were collected. Sensor-based gait parameters were captured during standardized 2 × 10 m and 2-min walk tests (2MWT) in the hospital and for 1 day of physical activity monitoring (PAM) at home. PAM was categorized by short (10-30 s), medium (30-60 s), and long (≥ 60 s) walking bouts (WB). Spearman correlations were applied to investigate associations between scores.
resultsMean gait velocity (GV) and stride length correlated more strongly with functional, clinical, and patient-reported scores in 2MWT than in 2 × 10 m. Additionally, the GV variability in the 2MWT correlated with BBS and PIGD (r = │0.3-0.7│), but was less prominent in 2 × 10 m (r = │0.0-0.5│). In PAM, GV of long WB correlated more strongly with the PIGD (r = │0.5-0.6│) than short WB (r = │0.2-0.4│).
conclusionThe 2MWT tended to show the highest construct validity. PAM offered complementary but weaker correlations, highlighting that PAM provides novel insights into daily life mobility of APD patients.
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