ArticleNature communications2026
Electrostatic properties of disordered regions control transcription factor search and pioneer activity.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Nucleosomes and IDRs suppress promiscuous GCN4 binding on minichromosomes.Nature structural & molecular biology · 2026Article
- Pioneer-factor activity requires stable chromatin occupancy mediated by both sequence-specific binding and disordered protein domains.Science advances · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription factors (TFs) search for and bind specific DNA target sites to control gene expression. However, eukaryotic TF target search within the chromatinized genome is poorly characterized. Here, we combine in vivo and in vitro single-molecule imaging to dissect the role of differentially-charged DNA-binding domain flanking regions in the target search of Sox TFs. We demonstrate that the flanking region of Sox2 markedly enhances search efficiency compared to the negatively-charged flanking region of Sox17. The involved mechanisms are distinct for naked DNA compared to chromatin. On DNA, the enhanced search of Sox2 is driven by an increased target recognition rate during 1D sliding, despite reduced sliding speed. Conversely, enhanced nonspecific interactions between the Sox2's DNA-binding domain flanking region and nucleosomes facilitate binding to compact chromatin and reinforce pioneer activity. These findings provide critical insights into biophysical mechanisms governing TF target search within the chromatinized genome.
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