ArticleScientific reports2026
Engineered biosynthesis of hyaluronic acid in Corynebacterium glutamicum and green synthesis of HA-silver nanocomposites for advanced antimicrobial wound dressings.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antibiotic resistance, a growing global challenge, is predicted to cause millions of deaths in the near future. Innovative antibacterial wound dressings loaded with natural substances that have restorative effects can serve as alternatives conventional medicine. This research aims to investigate the antibacterial properties of electrospun nanofibers containing different proportions of chitosan, collagen, and hyaluronic acid-silver nanocomposite. Silver nanoparticles (Ag NPs) were synthesized via a green, solvent‑free method, with hyaluronic acid (HA) obtained from recombinant Corynebacterium glutamicum fermentation serving as the natural reducing agent. with its production optimized using a full factorial design, resulting in a 26% yield increase under conditions of 10 g/L yeast extract, 20 g/L soy protein, and 400 mg/L MgSO₄. The purity of HA obtained from microbial fermentation was measured by Fourier-Transform Infrared spectroscopy. Silver nitrate concentrations of 0.01, 0.1, and 1 M were considered to synthesize nanoparticle precursors. Spectrophotometry and Dynamic Light Scattering analyses showed that 0.1 M AgNO
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