Evidence map›Paper›PMID 41656250›Full record

ArticleHarm reduction journal2026

Leveraging mHealth interventions to reduce sex- and drug-related risk behaviors among chemsex-involved men who have sex with men: evidence from a qualitative study.

Kamal Gautam, Christopher Uyar, Jeffrey A Wickersham, Kiran Paudel, Iskandar Azwa, Frederick L Altice, Md Safaet Hossain Sujan, Toan Ha, Michael M Copenhaver, Roman Shrestha

Abstract read
In one paragraph

Article in Harm reduction journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Kamal GautamDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.
Christopher UyarDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.
Jeffrey A WickershamSection of Infectious Diseases, Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
Kiran PaudelDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.
Iskandar AzwaFaculty of Medicine, Centre of Excellence for Research in Infectious Diseases & AIDS (CERiA), Universiti Malaya, Kuala Lumpur, Malaysia.
Frederick L AlticeSection of Infectious Diseases, Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
Md Safaet Hossain SujanDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.
Toan HaDepartment of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Michael M CopenhaverDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.
Roman ShresthaDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, USA. roman.shrestha@uconn.edu.

Funding

Optimizing a Just-in-Time Adaptive Intervention to Increase Uptake of Chemsex Harm Reduction Services in MSM: A Micro-randomized TrialR01DA061661 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI Roman Shrestha, Jeffrey Allen Wickersham · 2024 to 2026
$2.1M
Optimizing HIV Prevention Among Opioid-Dependent PersonsK24DA051344 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI MICHAEL COPENHAVER · 2020 to 2026
$1.3M
Training in MHealth Prevention with MSMK01DA051346 · NIDA · YALE UNIVERSITY · PI SHRESTHA, ROMAN · 2020 to 2024
$862k
Development and Testing of a Mobile Application to Enhance HIV Prevention Cascade in Malaysian MSMR21TW011665 · FIC · YALE UNIVERSITY · PI SHRESTHA, ROMAN · 2020 to 2021
$408k
FIC NIH HHS R21 TW011665NIDA NIH HHS K01 DA051346NIDA NIH HHS K01DA051346NIDA NIH HHS K24DA051344NIDA NIH HHS R01 DA061661
6 · The paper itself

Abstract

backgroundChemsex, a form of sexualized drug use, is a growing public health concern among men who have sex with men (MSM) in Malaysia. It is associated with an increased likelihood of HIV transmission and other adverse health outcomes, such as overdose. Although harm-reduction services are proven to be efficacious in mitigating these outcomes, they often remain inaccessible because of stigma, criminalization, and limited availability of the service. This study examines the barriers MSM face in such services and explores how a mobile smartphone app with tailored features could help overcome these barriers.

methodsFrom February to August 2022, six virtual focus groups were conducted with 22 MSM participants who had engaged in chemsex in the past six months. Participants were recruited through geosocial networking (GSN) applications and Facebook advertisements. The focus group sessions were recorded, transcribed, translated into English, and analyzed using thematic analysis.

resultsParticipants described multiple barriers to practicing chemsex harm reduction, including limited knowledge of safer drug use, peer pressure, fear of legal consequences, and stigma from healthcare providers. They emphasized the need for a mobile app that provides reliable educational resources, peer support groups, discreet ordering of harm-reduction supplies (e.g., condoms, lubricants, sterile injection equipment), and access to emergency assistance during adverse events. Privacy protection and a simple, familiar user interface were identified as essential for building trust and encouraging sustained use of the mobile app and uptake of harm reduction services among MSM.

conclusionsThis study underscores the persistent structural and social barriers to harm reduction among MSM who engage in chemsex in Malaysia. A mobile app tailored to their lived experiences and privacy needs may offer a confidential pathway to harm-reduction information, community support, and linkage to services that MSM trust.

Indexed as

ChemsexHarm ReductionHomosexuality, MaleMobile ApplicationsSubstance-Related DisordersAdultFocus GroupsHIV InfectionsHumansMalaysiaMaleMen's Health ServicesQualitative ResearchRisk-TakingTelemedicineYoung AdultChemsexHarm reductionMalaysiaMen who have sex with menmHealthSexualized drug useSmartphone app

Identifiers

PMID41656250
PMCPMC12983591

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.