Evidence map›Paper›PMID 41656243›Full record

ArticleJournal of nanobiotechnology2026

Zinc peroxide-copper bimetallic nanozyme with self-activated ROS and cuproptosis for superficial antifungal therapy.

Fuyao Chen, Yang Ye, Yitao Yao, Jian He, Xiaoning Yu, Renfang Zhang, Hailaiti Ailifeire, Chenqi Luo, Ke Yao, Xiajing Tang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fuyao Chen *Eye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, 310009, P.R. China.
Yang Ye *Eye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, 310009, P.R. China.
Yitao YaoState Key Laboratory of Fluid Power and Mechatronic Systems, Department of Mechatronics engineering, Zhejiang University, Hangzhou, 310000, China.
Jian HeZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), and Liangzhu Laboratory, Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, China.
Xiaoning YuEye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, 310009, P.R. China.
Renfang ZhangEye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, 310009, P.R. China.
Hailaiti AilifeireEye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, 310009, P.R. China.
Chenqi LuoEye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, 310009, P.R. China.
Ke YaoEye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, 310009, P.R. China.
Xiajing TangEye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, 310009, P.R. China. xiajingtang@zju.edu.cn.
Xingchao ShentuEye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, 310009, P.R. China. stxc@zju.edu.cn.

Funding

National Key Research and Development Program of China 2024YFC2510900/2024Y6FC2510904National Natural Science Foundation of China 82371037National Natural Science Foundation of China 82501358Postdoctoral Fellowship Program and China Postdoctoral Science Foundation 2024M762863Postdoctoral Science Preferential Funding of Zhejiang Province ZJ2024086
6 · The paper itself

Abstract

Fungal infections, particularly intractable cases such as fungal keratitis (FK) and skin wound infections, remain a pressing global health challenge, further exacerbated by rising antifungal resistance and treatment-associated cytotoxicity. Herein, we report a highly effective, non-antibiotic therapeutic strategy integrating reactive oxygen species (ROS) generation and cuproptosis via ZnO

Indexed as

Antifungal AgentsCopperReactive Oxygen SpeciesZincAnimalsBiofilmsCandida albicansCuproptosisHumansHydrogen PeroxideKeratitisMiceAntifungal AgentsCopperHydrogen PeroxideReactive Oxygen SpeciesZincCuproptosisFenton-like reaction.Fungal keratitisFungal wound infectionZinc-copper bimetallic peroxide

Identifiers

PMID41656243
PMCPMC12983616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.