Evidence map›Paper›PMID 41655871›Full record

ArticleAnnals of epidemiology2026

Suicide risks associated with cardiovascular disease in persons with alcohol use disorder.

Casey Crump, Jan Sundquist, Kristina Sundquist, Alexis C Edwards

Abstract read
In one paragraph

Article in Annals of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Casey CrumpDepartments of Family and Community Medicine and of Epidemiology, The University of Texas Health Science Center, 1133 John Freeman Boulevard, JJL 300, Houston, TX 77030, USA. Electronic address: casey.crump@uth.tmc.edu.
Jan SundquistCenter for Primary Health Care Research, Clinical Research Centre (CRC), Skåne University Hospital, building 28, floor 11, Jan Waldenströms gata 35, Malmö SE-205 02, Sweden. Electronic address: jan.sundquist@med.lu.se.
Kristina SundquistCenter for Primary Health Care Research, Clinical Research Centre (CRC), Skåne University Hospital, building 28, floor 11, Jan Waldenströms gata 35, Malmö SE-205 02, Sweden. Electronic address: Kristina.Sundquist@med.lu.se.
Alexis C EdwardsDepartment of Psychiatry, Virginia Commonwealth University, Bio-Technology Research Park, Building One, 800 E. Leigh Street, Suite 100, Richmond, VA 23298, USA. Electronic address: alexis.edwards@vcuhealth.org.

Funding

The Etiology of Risk: Alcohol Use Disorder and Suicidal BehaviorR01AA027522 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Alexis C Edwards, Kristina Sundquist · 2019 to 2026
$3.5M
NIAAA NIH HHS R01 AA027522
6 · The paper itself

Abstract

purposePeople with alcohol use disorder (AUD) have high risks of both cardiovascular disease (CVD) and suicide. We examined how CVD contributes to their long-term suicide risk in a large population-based cohort, which may help guide preventive interventions.

methodsA national cohort study was conducted of all 537,802 people with AUD in Sweden during 1973-2017. CVD and suicide deaths were ascertained from nationwide records through 2018. Cox regression was used to determine hazard ratios (HRs) for suicide death associated with ischemic heart disease, stroke, heart failure, or atrial fibrillation, and a composite outcome ("any CVD"), adjusting for other mental disorders and sociodemographic factors.

resultsAny CVD was associated with a 1.4-fold risk of death by suicide (adjusted HR, 1.44; 95 % CI, 1.35-1.54). Adjusted HRs by specific comorbidities were: ischemic heart disease, 1.26 (95 % CI, 1.16-1.38); stroke, 1.45 (1.31-1.61); heart failure, 1.49 (1.31-1.69); and atrial fibrillation, 1.52 (1.36-1.70). These risks were similarly elevated in men and women.

conclusionsIn this large national cohort with AUD, CVD was associated with a ∼40 % higher risk of suicide death. Clinical care for persons with AUD should integrate mental health and prevention and treatment of CVD comorbidities to support their long-term health and survival.

Indexed as

AlcoholismCardiovascular DiseasesSuicideAdultAgedCohort StudiesComorbidityFemaleHumansMaleMiddle AgedProportional Hazards ModelsRisk FactorsSwedenAlcoholismCardiovascular diseasesComorbiditySubstance-related disordersSuicide

Identifiers

PMID41655871
PMCPMC13339885

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.