ArticleMagnetic resonance imaging2026
Large gains in SNR through the application of Shinnar-Le Roux RF pulse design to short-TR spin-echo fMRI acquisitions at 7 T.
Mukund Balasubramanian, Robert V Mulkern, William A Grissom, Jonathan R Polimeni
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In one paragraphArticle in Magnetic resonance imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
Mukund BalasubramanianHarvard Medical School, Boston, MA, USA; Department of Radiology, Boston Children's Hospital, Boston, MA, USA. Electronic address: mukund.balasubramanian@childrens.harvard.edu.
Robert V MulkernHarvard Medical School, Boston, MA, USA; Department of Radiology, Boston Children's Hospital, Boston, MA, USA.
William A GrissomDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Jonathan R PolimeniRichard M. Lucas Center for Imaging, Stanford University, Stanford, CA, USA; Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
Funding
Viral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectorsU19NS128613 · NINDS · UNIVERSITY OF ROCHESTER · PI Patrick James Drew, Hajime Hirase · 2022 to 2026
$13.6MProject 4U19NS123717 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LINNINGER, ANDREAS A · 2021 to 2025
$13.4MTraining and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BRUCE R ROSEN · 2020 to 2026
$10.9MfMRI Technologies for Imaging at the Limit of Biological Spatiotemporal Resolution: Administrative SupplementR01EB019437 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI POLIMENI, JONATHAN RIZZO, SETSOMPOP, KAWIN · 2015 to 2024
$5.5MThree-Dimensional Patient-Tailored RF Pulses for Spin Echo Neuroimaging at 7 TR01EB016695 · NIBIB · VANDERBILT UNIVERSITY · PI GRISSOM, WILLIAM A · 2014 to 2021
$3.8MSystem Upgrade for Siemens 7T Human MRI SystemS10OD023637 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI WALD, LAWRENCE L · 2017 to 2017
$2.0MCRCNS: Waste-clearance flows in the brain measured using physics-informed neural networkR01AT012312 · NCCIH · UNIVERSITY OF ROCHESTER · PI Douglas H Kelley · 2022 to 2026
$1.6MResolving Human Brain Activation Across Cerebral Cortical Layers with Line-Scan Functional MRIR01NS136385 · NINDS · STANFORD UNIVERSITY · PI POLIMENI, JONATHAN R · 2024 to 2025
$1.3MAn acquisition and reconstruction framework to enable mesoscale human fMRI on clinical 3 Tesla scannersR01EB033206 · NIBIB · STANFORD UNIVERSITY · PI SETSOMPOP, KAWIN · 2022 to 2022
$853kNCCIH NIH HHS R01 AT012312NIBIB NIH HHS P41 EB030006NIBIB NIH HHS R01 EB016695NIBIB NIH HHS R01 EB019437NIBIB NIH HHS R01 EB033206NIH HHS S10 OD023637NINDS NIH HHS R01 NS136385NINDS NIH HHS U19 NS123717NINDS NIH HHS U19 NS128613
6 · The paper itselfAbstract
purposeThe optimal excitation flip angle (FA) for short-TR spin-echo acquisitions can be well above 90°, far beyond the small FAs suited for commonly-used sinc RF pulses. The goal of this study was to characterize the benefits of Shinnar-Le Roux (SLR) over sinc pulses for these acquisitions, which may lead to improvements in the temporal and spatial specificity of fMRI.
methodsSlice profiles were obtained either through Bloch simulation or from scans of an oil phantom at 7 T (T
resultsFor 2D acquisitions with the parameter values used here, the high-quality slice profiles provided by the SLR pulses resulted in an SNR gain of ∼100% relative to sinc pulses. For 1D linescan acquisitions, the SNR gains were even higher: ∼150%.
conclusionsThe large gains in SNR described here should enhance any studies using short-TR spin-echo acquisitions; in particular, we anticipate application of these SLR pulses to fMRI studies that target the microvasculature with both high spatial and high temporal resolution. Potential limitations, due to high SAR or B
Indexed as
BrainImage EnhancementImage Interpretation, Computer-AssistedMagnetic Resonance ImagingAlgorithmsBrain MappingHumansImage Processing, Computer-AssistedPhantoms, ImagingRadio WavesReproducibility of ResultsSensitivity and SpecificitySignal-To-Noise RatioSpin LabelsSpin LabelsHigh-resolution fMRIRadiofrequency (RF) pulse designSlice profilesSpin echoUltra-high field (UHF) MRI
Identifiers
PMID41655659
PMCPMC12984075
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