Evidence map›Paper›PMID 41655262›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Engineered TIGIT-Blockade Membrane Vesicles Synergize with Microwave Ablation to Mediate Liver Metastases Eradication.

Shaoyue Li, Weichen Xu, Yuting Shen, Xuexia Shan, Jiawei Sun, Shisi Ding, Xiaodong Hou, Shaoning Zhang, Zhiyuan Niu, Taixia Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shaoyue LiDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, P. R. China.
Weichen XuDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, P. R. China.
Yuting ShenDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Xuexia ShanDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, P. R. China.
Jiawei SunDepartment of In-patient Ultrasound, the Second Affiliated Hospital, Harbin Medical University, Harbin, P. R. China.
Shisi DingDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, P. R. China.
Xiaodong HouDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, P. R. China.
Shaoning ZhangDepartment of In-patient Ultrasound, the Second Affiliated Hospital, Harbin Medical University, Harbin, P. R. China.
Zhiyuan NiuDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, P. R. China.
Taixia WangDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, P. R. China.
Xin GuanDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Xiao LiDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Weiwei RenDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, P. R. China.
Dou DuDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, P. R. China.
Huixiong XuDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0002-1977-0449
Wenwen YueDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, P. R. China.
Liping SunDepartment of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, School of Medicine, Tongji University, Shanghai, P. R. China.

Funding

China Postdoctoral Science Foundation 2025MD784136National Natural Science Foundation of China 82151318National Natural Science Foundation of China 82171945Natural Science Foundation of Heilongjiang Province JJ2025QC0429Shanghai Anti-Cancer Association SACA-CY25B06Shanghai Municipal Health Commission SHSLCZDZK03502
6 · The paper itself

Abstract

Microwave ablation (MWA) represents a highly effective and clinically significant therapeutic modality for the treatment of liver metastases. The proliferation of disseminated tumor cells within the peri-necrotic transition zone (TZ) is a critical factor contributing to the postablative recurrence; to date, no effective method has been identified to specifically target and eliminate these cells. Here, based on an experimental liver metastases model, we leverage single-cell RNA sequencing and flow cytometry analysis, which reveals that TZ exhibits a VEGF-mediated immunosuppressive microenvironment, characterized by a significant increase of CD155

Indexed as

Liver NeoplasmsMicrowavesReceptors, ImmunologicAnimalsFemaleHumansMiceReceptors, ImmunologicCD155/TIGIT blockadeengineered membrane vesiclesgenetic engineeringliver metastasesmicrowave ablation

Identifiers

PMID41655262
PMCPMC13088283

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.