Evidence map›Paper›PMID 41655257›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Metal-Supramolecular Drug Delivery System Empowered Meningeal Lymphatic Vessels-Bridged Intracranial-Peripheral Dual Immune Modulation for Reversing Glioblastoma Immune Suppression.

Chenxi Zhang, Zhongsheng Xu, Xiaowen Xu, Zening Zhang, Ranran Luo, Pengchen Ren, Yingying Luo, Qiuchi Wu, Xinyu Liu, Guodong Liu and 2 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chenxi ZhangDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhongsheng XuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiaowen XuDepartment of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zening ZhangDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ranran LuoDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Pengchen RenDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yingying LuoDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qiuchi WuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xinyu LiuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Guodong LiuDepartment of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiaojing HeDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yun LiuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-7761-309X

Funding

Chongqing Returned Overseas Students' Entrepreneurship and Innovation Support Program cx2021006CQMU Program for Youth Innovation in Future Medicine W0171Kuanren Doctoral Supervisor Cultivation Program and Kuanren Talents Program of the Second Affiliated Hospital of CQMUKuanren Talent Reserve Program for Academic&Technical Leadership 2025-53Natural Science Foundation of Chongqing CSTB2024NSCQ-MSX0394Senior Medical Talents Program of Chongqing for Young and Middle-aged
6 · The paper itself

Abstract

Glioblastoma (GBM) presents significant challenges in treatment due to the presence of the blood-brain barrier (BBB) and immunosuppressive tumor microenvironment (TME). Here, we developed a novel metal-supramolecular delivery system (FLM@VC) that empowers meningeal lymphatic vessels (MLVs)-bridged intracranial-peripheral dual immune modulation to reverse GBM immune suppression. Using coordination-driven self-assembly of lipoic acid (LA), iron ions (Fe

Indexed as

Brain NeoplasmsDrug Delivery SystemsGlioblastomaLymphatic VesselsAnimalsBlood-Brain BarrierCell Line, TumorHumansMeningesMiceTumor Microenvironmentglioblastomaimmunotherapymeningeal lymphatic vesselstumor‐associated macrophagesvascular endothelial growth factor C

Identifiers

PMID41655257
PMCPMC13088265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.