Evidence map›Paper›PMID 41655210›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC-I Antigen Presentation That Promotes Tumor Immune Evasion.

Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lei ZhaoDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Linlin ShengSchool of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China.
Jianhao QiuDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Junjie MaDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Kai JinDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Binggong ZhaoDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Tianrun MiaoDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Jing ChenDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Yehong LiDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Zhan ZhangDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Dongfeng SunDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Yongmeng LiDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Hui TianDepartment of Thoracic Surgery, Shandong Key Laboratory of Digital Diagnosis and Treatment of Thoracic Oncology, Shandong Engineering Research Center of Intelligent Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.ORCID https://orcid.org/0000-0003-4516-2313

Funding

China Postdoctoral Science Foundation 2025M782124Joint Innovation Team for Clinical & Basic Research 202409National Natural Science Foundation of China 81672292National Natural Science Foundation of China 82472814Natural Science Foundation of Shandong Province ZR2021LSW006Natural Science Foundation of Shandong Province ZR2024QH274Postdoctoral Innovation Seed Cultivation Program SDZZ-ZR-202501085Taishan Scholar Program of Shandong Province TS201712087
6 · The paper itself

Abstract

Immune checkpoint blockade (ICB) efficacy is limited by tumor-intrinsic immune escape mechanisms. This study identifies the transcription factor ZBTB21 as a central orchestrator of dual immunosuppressive programs. ZBTB21 epigenetically silences gasdermin D (GSDMD)-dependent pyroptosis by restricting STAT1-mediated chromatin accessibility via H3K27ac modulation at the GSDMD locus. Simultaneously, it represses MHC-I antigen presentation by attenuating IRF1 expression and its transactivation capacity. Genetic ablation of ZBTB21 unleashes pyroptotic cell death and enhances tumor antigen presentation, establishing a self-reinforcing cycle that recruits and activates CD8

Indexed as

Antigen PresentationHistocompatibility Antigens Class IPyroptosisRepressor ProteinsTumor EscapeAnimalsHumansMiceHistocompatibility Antigens Class IRepressor Proteinsimmune checkpoint blockadeMHC‐Ipyroptosistumor immune evasionZBTB21

Identifiers

PMID41655210
PMCPMC13088348

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.