Evidence map›Paper›PMID 41655181›Full record

ArticleClinical and experimental medicine2026

Monitoring cancer-related fatigue and quality of life in breast and prostate cancer patients after primary treatment: a study protocol for the REBECCA trials in Norway.

Marius Stensland, Karina F Bru, Marie Austdal, Ingrid H Dahl, Kristin Jonsdottir, Tone H Lende, Cato Heimvik, Inger Elve, Roald Omdal, Mark van der Giezen and 18 more

3 registry-linked trialsAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05587777 recruitingnot on this map

REsearch on BrEast Cancer Induced Chronic Conditions Supported by Causal Analysis of Multi-source Data

TypeobservationalSponsorHelse Stavanger HFRan2022 to 2028Enrolled150ConditionsBreast Cancer, Chronic Fatigue Syndrome
NCT06120595 naunknown statusnot on this map

REBECCA-2 Study: Research on Breast Cancer Induced Chronic Conditions Supported by Causal Analysis of Multi-source Data

TypeinterventionalSponsorHelse Stavanger HFRan2022 to 2025Enrolled81ConditionsCancer Related FatigueArmsREBECCA-assisted intervention 1, REBECCA-assisted intervention 2, Standard follow-up
NCT06435091 active not recruitingnot on this map

REBECCA-3 Study, Research on Breast Cancer Induced Chronic Conditions Supported by Causal Analysis of Multi-source Data

TypeobservationalSponsorHelse Stavanger HFRan2023 to 2025Enrolled40ConditionsCancer Related Fatigue
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Marius StenslandDepartment of Hematology and Oncology, Stavanger University Hospital, Stavanger, 4068, Norway. marius.stensland@sus.no.
Karina F BruResearch Department, Stavanger University Hospital, Stavanger, 4068, Norway.
Marie AustdalResearch Department, Stavanger University Hospital, Stavanger, 4068, Norway.
Ingrid H DahlDepartment of Hematology and Oncology, Stavanger University Hospital, Stavanger, 4068, Norway.
Kristin JonsdottirResearch Department, Stavanger University Hospital, Stavanger, 4068, Norway.
Tone H LendeDepartment of Surgery, Stavanger University Hospital, Stavanger, 4068, Norway.
Cato HeimvikDepartment of Information Systems, Stavanger University Hospital, Stavanger, 4068, Norway.
Inger ElveDepartment of Hematology and Oncology, Stavanger University Hospital, Stavanger, 4068, Norway.
Roald OmdalResearch Department, Stavanger University Hospital, Stavanger, 4068, Norway.
Mark van der GiezenResearch Department, Stavanger University Hospital, Stavanger, 4068, Norway.
Ingeborg KvivikResearch Department, Stavanger University Hospital, Stavanger, 4068, Norway.
Berthine TangelandStavanger University Hospital, Pusterommet, Stavanger, 4068, Norway.
Lisbeth DavidsenStavanger University Hospital, Pusterommet, Stavanger, 4068, Norway.
Masood HashemiDepartment of Urology, Stavanger University Hospital, Stavanger, 4068, Norway.
Adam CaisDepartment of Urology, Stavanger University Hospital, Stavanger, 4068, Norway.
Karlijn J van DijkDepartment of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, 4021, Norway.
Yohannes SeyoumDepartment of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, 4021, Norway.
Vibeke BlåfjelldalDepartment of Surgery, Stavanger University Hospital, Stavanger, 4068, Norway.
Siri Tungland SolaResearch Department, Stavanger University Hospital, Stavanger, 4068, Norway.
Alexandros PapadopoulosDepartment of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Niki KiriakidouDepartment of Informatics and Telematics, Harokopio University of Athens, Omirou 9, Tavros, Athens, 17778, Greece.
Ioannis IoakeimidisDepartment of Medicine, Huddinge, Gastroenterology and Nutrition Unit, Karolinska Institute, 141 52, Huddinge/Stockholm, Stockholm, Sweden.
Christos DiouDepartment of Informatics and Telematics, Harokopio University of Athens, Omirou 9, Tavros, Athens, 17778, Greece.
Ioannis SarafisDepartment of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Anastasios DelopoulosDepartment of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Emiel A M JanssenDepartment of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, 4021, Norway.
Bjørnar GiljeDepartment of Hematology and Oncology, Stavanger University Hospital, Stavanger, 4068, Norway.
Kjersti TjensvollDepartment of Hematology and Oncology, Stavanger University Hospital, Stavanger, 4068, Norway.

Funding

Horizon 2020 Framework Programme 965231
6 · The paper itself

Abstract

The REBECCA project taps into the potential of using real-world data (RWD) for supporting groundbreaking clinical research on complex chronic conditions as a complement to Randomised Controlled Trials. REBECCA moves beyond the analysis of clinical data from Electronic health records, by combining it with detailed monitoring data from multiple wearables, online behaviour and self-reported data to monitor patients's quality of life in terms of their functional and emotional status. The project focuses on the detection of cancer-related fatigue, developed during breast cancer recovery, using digital biomarker profiles for early detection of the disease and assessing the value of detailed and longitudinal patient monitoring as a means of improving patient care. The project also demonstrates the extensibility of REBECCA monitoring to other forms of cancer, such as prostate cancer. We describe the three clinical trials being conducted in Norway and the use of the REBECCA platform, capable of detailed monitoring and privacy preserving federated cross-country data analysis. The RWD will be analyzed in the context of data from questionnaires (Patient Reported Outcome Measures) and results from analysis of biological samples. Through this approach we expect that the REBECCA project will produce new knowledge on clinical management of cancer patients and contribute to new biological knowledge on cancer-related fatigue. Status and perspectives: The REBECCA project is ongoing, and patient follow-up will be completed during February 2026. The initial analyses of RWD, PROMs and biological samples have started together with the partners in the REBECCA consortium. The REBECCA trials are approved by the Regional Ethics Committee of the Western Health Authority (REK Vest) under the IDs 225,855 (REBECCA-1), 242,088 (REBECCA-2) and 619,903 (REBECCA-3). All trials have also been registered at clinicaltrials.gov (NCT05587777, NCT06120595 and NCT06435091). Trial registration: NCT05587777, Retrospectively registered 19th of October 2022, https://clinicaltrials.gov/study/ NCT05587777; NCT05587777, Retrospectively registered 6th of November 2023, https://clinicaltrials.gov/study/ NCT06120595; NCT05587777, Retrospectively registered 23rd of May 2024, https://clinicaltrials.gov/study/ NCT06435091.

Indexed as

Breast NeoplasmsFatigueProstatic NeoplasmsQuality of LifeFemaleHumansMaleNorwayObservational Studies as TopicPatient Reported Outcome MeasuresRandomized Controlled Trials as TopicBiological samplesBreast cancerCancer-related fatiguePROMProstate cancerQuality of lifeReal-world dataWearables

Identifiers

PMID41655181
PMCPMC12886262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.