Evidence map›Paper›PMID 41655127›Full record

ArticleAging cell2026

Plasma Proteome Profiling of Centenarian Across Switzerland Reveals Key Youth-Associated Proteins.

Flavien Delhaes, Justine Falciola, Adar Hoffman, Stéphanie Carnesecchi, Stefano Cavalli, Armin von Gunten, Daniela S Jopp, François R Herrmann, Karl-Heinz Krause

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Flavien DelhaesDivision and Department of Geriatrics and Rehabilitation, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.ORCID 0000-0002-8127-6054
Justine FalciolaDivision and Department of Geriatrics and Rehabilitation, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.ORCID 0000-0002-1135-9321
Adar HoffmanInstitute of Psychology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-5280-2801
Stéphanie CarnesecchiDepartment of Education, Medical University of Geneva, Geneva, Switzerland.
Stefano CavalliCentre of Competence on Ageing, University of Applied Sciences and Arts of Southern Switzerland (SUPSI), Manno, Switzerland.ORCID 0000-0002-5329-9558
Armin von GuntenOld-Age Psychiatry Service, Department of Psychiatry, University Hospital Lausanne, Prilly, Switzerland.
Daniela S JoppInstitute of Psychology, University of Lausanne, Lausanne, Switzerland.
François R HerrmannDivision and Department of Geriatrics and Rehabilitation, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.
Karl-Heinz KrauseFoundation for Medical Research, Geneva, Switzerland.

Funding

Swiss National Science Foundation (SNSF) 186239
6 · The paper itself

Abstract

Centenarians exhibit remarkable longevity and compression of morbidity making them an ideal population for uncovering proteins associated with successful aging. Using proteomics, we characterized the immune and cardiometabolic profiles of centenarians' plasma from the SWISS100 cohort. We identified 583 differentially expressed proteins (DEPs) by centenarians when compared with hospitalized geriatric patients (age 80-90 years) and younger healthy participants (age 30-60 years). We replicated the association of 23 proteins with a standard set of aging proteins (APs) developed by the Targeting Aging with Metformin (TAME) consortium. By comparing the centenarian signature to an independent centenarian proteomics study, we identified 135 DEPs in both studies with identical aging directions, establishing a robust set of APs in centenarians. Applying fractional polynomial regressions, we uncovered proteins with linear and non-linear profiles associated with age and identified a subgroup of 37 proteins with a younger signature in centenarians. Protein-protein interaction and pathway enrichment analyses of 37 proteins point to programmed cell death, metabolic enzyme pathways, regulation of extracellular matrix stability, immune and inflammatory responses, and neurotrophic signaling pathways. This novel approach to aging research has uncovered new proteins and pathways, which may present promising targets to understand processes associated with longevity and healthy aging.

Indexed as

AgingBlood ProteinsProteomeProteomicsAged, 80 and overFemaleHumansLongevityMaleMiddle AgedSwitzerlandBlood ProteinsProteomeagingcentenarianhealthspaninflammationmetabolismplasmaproteomics

Identifiers

PMID41655127
PMCPMC12883144

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.