Evidence map›Paper›PMID 41655077›Full record

ArticleJournal of separation science2026

Supercritical Carbon Dioxide Extraction With Dimethyl Carbonate and Bio-Ethanol as Co-Solvents for the Determination of Pesticide Residues in Black Pepper by Low-Pressure Gas Chromatography-Triple Quadrupole Mass Spectrometry.

Alessia Arena, Mariosimone Zoccali, Luigi Mondello

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of separation science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alessia ArenaChromaleont S.R.L., c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Mariosimone ZoccaliDepartment of Mathematical and Computer Science, Physical Sciences and Earth Sciences, University of Messina, Messina, Italy.
Luigi MondelloChromaleont S.R.L., c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.

Funding

the Division of Analytical Chemistry of the European Chemical Society
6 · The paper itself

Abstract

The determination of pesticide residues in spices is analytically challenging due to their high content of essential oils and secondary metabolites that could interfere with detection and quantification. In this study, supercritical fluid extraction (SFE), using green co-solvents, was evaluated for the extraction of 44 pesticides from black pepper (Piper nigrum). The extraction performance of bio-ethanol (bio-EtOH) and dimethyl carbonate (DMC) was compared under mild operating conditions. Optimal recoveries were obtained with 10% DMC, yielding an average of 92.6% across 44 pesticides, comparable to 93.7% using bio-EtOH. Method performance was assessed by low-pressure gas chromatography-triple quadrupole mass spectrometry (LP-GC-QqQMS). Linearity was achieved over the tested range, with limits of detection (within the range 0.1-17.9 µg kg

Indexed as

Chromatography, Supercritical FluidFormatesPesticide ResiduesPiper nigrumCarbon DioxideEthanolGas Chromatography-Mass SpectrometrySolventsCarbon DioxideEthanolFormatesmethyl carbonatePesticide ResiduesSolventsblack peppergreen solventspesticidesPiper nigrumsupercritical fluid extraction

Identifiers

PMID41655077
PMCPMC12883146

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.