Evidence map›Paper›PMID 41655014›Full record

ArticleBiophysical journal2026

Experimentally informed, quantitative photocycle model of the light-gated potassium channel WiChR.

Sophia Ohnemus, Linda Tillert, Roberta De Zio, Raluca-Andreea Tifrea, Andries Napo Leemisa, Simon Beyer, Peter Kohl, Viviane Timmermann, Franziska Schneider-Warme, Johannes Vierock

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sophia OhnemusInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg - Bad Krozingen, Medical Faculty and Medical Center - University of Freiburg, 79110 Freiburg im Breisgau, Germany; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg im Breisgau, Germany; Faculty of Mathematics and Physics, University of Freiburg, 79104 Freiburg im Breisgau, Germany.
Linda TillertCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Neurocure Cluster of Excellence, Charitéplatz 1, 10117 Berlin, Germany; Institute for Biology, Humboldt-Universität zu Berlin, 10099 Berlin, Germany.
Roberta De ZioInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg - Bad Krozingen, Medical Faculty and Medical Center - University of Freiburg, 79110 Freiburg im Breisgau, Germany; Department of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, Italy.
Raluca-Andreea TifreaCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Neurocure Cluster of Excellence, Charitéplatz 1, 10117 Berlin, Germany.
Andries Napo LeemisaInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg - Bad Krozingen, Medical Faculty and Medical Center - University of Freiburg, 79110 Freiburg im Breisgau, Germany; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg im Breisgau, Germany.
Simon BeyerFaculty of Mathematics and Physics, University of Freiburg, 79104 Freiburg im Breisgau, Germany; CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg im Breisgau, Germany.
Peter KohlInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg - Bad Krozingen, Medical Faculty and Medical Center - University of Freiburg, 79110 Freiburg im Breisgau, Germany; CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg im Breisgau, Germany.
Viviane TimmermannFaculty of Mathematics and Physics, University of Freiburg, 79104 Freiburg im Breisgau, Germany; CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg im Breisgau, Germany; Faculty of Medicine, University of Freiburg, 79110 Freiburg im Breisgau, Germany.
Franziska Schneider-WarmeInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg - Bad Krozingen, Medical Faculty and Medical Center - University of Freiburg, 79110 Freiburg im Breisgau, Germany; CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg im Breisgau, Germany. Electronic address: franziska.schneider.uhz@uniklinik-freiburg.de.
Johannes VierockCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Neurocure Cluster of Excellence, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: johannes.vierock@charite.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Light-gated ion channels (channelrhodopsins; ChRs) can be used to precisely control the electrical activity of genetically targeted cell populations with light. Although nonselective cation ChRs are widely used to elicit action potentials (APs) in excitable cells, the recently identified class of K

Indexed as

Ion Channel GatingLightModels, BiologicalAnimalsPotassiumPotassium

Identifiers

PMID41655014
PMCPMC13351580

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.