ArticleAnimal microbiome2026
Dual probiotic intervention with Lactiplantibacillus plantarum Kmiate-6 and Pediococcus acidilactici Kmiate-15 improves periodontal health and oral microbiota balance in dogs.
Article in Animal microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
backgroundPeriodontal disease is highly prevalent in dogs, yet current treatments such as dental scaling and antibiotics carry limitations including anesthesia risks, high recurrence, and antibiotic resistance. Probiotics have emerged as a promising strategy to modulate oral microbiota and host inflammation. This study evaluated the effects of dual probiotic intervention with Lactiplantibacillus plantarum Kmiate-6 and Pediococcus acidilactici Kmiate-15 on canine oral health through in vitro and in vivo assays.
resultsBoth strains exhibited antimicrobial activity against common oral pathogens, with Lactiplantibacillus plantarum Kmiate-6 showing stronger inhibition against Streptococcus mutans, Fusobacterium nucleatum, and Streptococcus mitis, while Pediococcus acidilactici Kmiate-15 demonstrated superior anti-inflammatory effects by reducing tumor necrosis factor-alpha and increasing interleukin-10 production. In vivo, 21-day oral administration of the probiotic combination significantly reduced dental plaque area and plaque index in dogs, along with decreased salivary tumor necrosis factor-alpha and elevated interleukin-10 levels. Microbiota analysis showed that probiotic intervention decreased the abundance of pathogenic genera such as Fusobacterium and Porphyromonas, and enriched beneficial taxa including Actinomyces and Weissella. Functional predictions based on 16S ribosomal RNA gene data indicated that probiotic treatment enhanced pathways related to detoxification, antioxidation, and propanoate metabolism, while reducing reliance on vitamin biosynthesis pathways typically exploited by pathogens.
conclusionsCombined oral administration of Lactiplantibacillus plantarum Kmiate-6 and Pediococcus acidilactici Kmiate-15 effectively improved canine periodontal health by inhibiting plaque formation, modulating inflammatory responses, and reshaping oral microbial composition and function. These findings support the potential of probiotic-based strategies as safe and effective alternatives for maintaining oral health in dogs.
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