ArticleBMC cancer2026
The role of surgery plus radiation versus surgery alone in the management for complicated orbital solitary fibrous tumor: a new insight on a rare disease.
Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Pediatric orbital solitary fibrous tumor/hemangiopericytoma presenting with isolated eyelid edema: a case report.Frontiers in pediatrics · 2026Article
- Primary orbital solitary fibrous tumor with an 18-year course of five recurrences and extensive sinonasal metastasis following eyeball enucleation: a case report.Frontiers in medicine · 2026Article
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4 authors.
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Abstract
backgroundOrbital solitary fibrous tumor is extremely rare, and the therapeutic role of radiotherapy remains poorly defined. This study aimed to compare long-term prognosis between surgery plus radiotherapy and surgery alone in complicated orbital solitary fibrous tumor (OSFT), thereby providing evidence-based insights for clinical management. METHODS AND MATERIALS: In this retrospective cohort study, we analyzed OSFT patients treated over a decade (January 2013-December 2023). Inclusion criteria encompassed cases with tumor recurrence or histopathological confirmation of anaplastic /malignant variants. By excluding benign cases without recurrence, we could specifically examine the impact of radiotherapy on disease control in complicated OSFTs. Clinico-demographic parameters including age, gender, histopathological subtype, surgical intervention, and radiotherapy administration were collected. Patients were stratified into two treatment arms: surgery alone (n = 19) versus surgery with adjuvant radiotherapy (n = 15). Kaplan-Meier methodology was employed to evaluate recurrence-free survival (RFS) and overall survival (OS), with between-group comparisons using log-rank tests. Cox proportional hazards models were implemented for prognostic factor analysis.
resultsFrom 60 screened OSFT cases, 34 met inclusion criteria: 13 anaplastic, 11 malignant, and 10 recurrent tumors at presentation. The surgery combining radiotherapy cohort demonstrated superior 3-year (88.9% vs. 51.3%) and 5-year RFS (88.9% vs. 44.0%) compared to surgery alone (P = 0.036). A self-controlled analysis of irradiated patients revealed significant post-radiotherapy reduction in recurrence rates (P = 0.025). Univariate Cox analysis identified radiotherapy administration as the sole independent prognostic factor (HR = 0.24).
conclusionLong-term follow-up demonstrates that adjuvant radiotherapy combined with surgical resection significantly enhanced local control in complicated OSFT, with acceptable radiation-related toxicity profiles.
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