Evidence map›Paper›PMID 41654747›Full record

SynthesisBMC infectious diseases2026

Global prevalence, mortality, and comorbidities of patients with diabetes mellitus and proven Candida auris emerging infection: a systematic review & meta-analysis.

Aydin Vaez, Arman Ghahremanzadeh, Farshad Zare, Sanam Nami, Faranak Zargari, Sina Najafi, Ainaz Zamani, Seyedyashar Pourebrahimian Leilabadi, Hesam Farajzadeh Asl, Hamid Morovati

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aydin Vaez *Department of Infectious Disease, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Arman Ghahremanzadeh *Department of Internal Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Farshad ZareStudent Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Sanam NamiDepartment of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Faranak ZargariStudent Research Committee, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
Sina NajafiDepartment of Infectious Disease, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Ainaz ZamaniMaragheh University of Medical Sciences, Maragheh, Iran.
Seyedyashar Pourebrahimian LeilabadiStudent Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Hesam Farajzadeh AslStudent Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Hamid MorovatiDepartment of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. morovatihamid1989@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCandida auris is an emerging multidrug-resistant yeast pathogen with several risk factors, including diabetes mellitus (DM). This study analyzed the epidemiological aspects of C. auris patients with DM (CaDM). We searched related databases without time and linguistic limitations for studies reporting DM among patients with proven C. auris infection (PCaI).

methodsA meta-analysis was conducted using STATA (version 17) with the random-effects model based on DerSimonian and Laird methods, employing the metan and metaprop commands.

resultsA total of 43 studies were included. Our random effect model reached the pooled prevalence of 36% (p value: < 0.001) for DM among patients with PCaI. The prevalence of DM among PCaI patients is almost 40% higher than non-auris patients (OR: 1.40; p value: < 0.001). Men with DM were 46% lower susceptibility to C. auris infection compared to women (OR: 0.54; p value: 0.905). However, this was not statistically significant. Our results showed that 57% of unadjusted all-cause mortality were recorded among CaDM patients (p value: 0.03). Chronic kidney diseases (CKD), hypertension (HTN), and respiratory diseases (RD) were the most frequent comorbidities. Central venous catheter (CVC), ICU stay, and mechanical ventilation were the most frequent hospital-related factors.

conclusionsWe concluded that despite the significant advances in diagnosis and treatments, prevalence, risk, and mortality rates of C. auris infection and diabetes mellitus remained high.

Indexed as

Candida aurisCandidiasisCommunicable Diseases, EmergingDiabetes ComplicationsDiabetes MellitusCandidiasis, InvasiveComorbidityFemaleGlobal HealthHumansMalePrevalenceRisk FactorsCandida aurisDiabetes mellitusEpidemiologyMeta-analysisMortalityPrevalence

Identifiers

PMID41654747
PMCPMC12977804

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.