Evidence map›Paper›PMID 41654719›Full record

ArticleBMC geriatrics2026

Association of multimorbidity with mortality risk in Chinese senior adults: a population-based cohort study.

Ming Gui, Chuan-Jiang Chen, Yufeng Chen, Fan Wen, Yongqi Wang, Yiting Tan, Zuyi Feng, Jun Yun, Zhelin Yang, Dexing Zhang and 2 more

Abstract read
In one paragraph

Article in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ming Gui *School of Public Health, Guangdong Pharmaceutical University, 283 Jianghai Avenue, Haizhu District, Guangzhou, 510310, China.
Chuan-Jiang Chen *School of Public Health, Guangdong Pharmaceutical University, 283 Jianghai Avenue, Haizhu District, Guangzhou, 510310, China.
Yufeng Chen *Department of Community Health Service, Guangzhou Yuexiu District Center for Disease Prevention and Control, Guangzhou, 510080, China.
Fan WenDepartment of Community Health Service, Guangzhou Yuexiu District Center for Disease Prevention and Control, Guangzhou, 510080, China.
Yongqi WangSchool of Public Health, Guangdong Pharmaceutical University, 283 Jianghai Avenue, Haizhu District, Guangzhou, 510310, China.
Yiting TanSchool of Public Health, Guangdong Pharmaceutical University, 283 Jianghai Avenue, Haizhu District, Guangzhou, 510310, China.
Zuyi FengSchool of Public Health, Guangdong Pharmaceutical University, 283 Jianghai Avenue, Haizhu District, Guangzhou, 510310, China.
Jun YunDepartment of Infectious Disease Control, Guangzhou Baiyun District Center for Disease Prevention and Control, Guangzhou, 510440, China.
Zhelin YangSchool of Public Health, Guangdong Pharmaceutical University, 283 Jianghai Avenue, Haizhu District, Guangzhou, 510310, China.
Dexing ZhangSchool of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Xudong LiuSchool of Public Health, Guangdong Pharmaceutical University, 283 Jianghai Avenue, Haizhu District, Guangzhou, 510310, China. xdliu.cn@hotmail.com.
Wenjing ZhaoSchool of Public Health and Emergency Management, Southern University of Science and Technology, No.1088 Xueyuan Dadao, Nanshan District, Shenzhen, 518055, China. zhaowj@sustech.edu.cn.

Funding

Clinical Research Fund of Guangdong Medical Association 2025MB-A1063Guangdong Basic and Applied Basic Research Foundation 2022A1515010686Shenzhen Medical Research Fund B2303004
6 · The paper itself

Abstract

backgroundThis study aimed to evaluate the association of three multimorbidity indicators with mortality risk among senior adults, and compare their predictive performance on mortality risk.

methodsThis prospective cohort study was conducted using data from the Yuexiu Ageing and Health Cohort, a dynamic cohort established since January 2016. Annual health examination is conducted for the senior adults aged ≥ 65 years in the jurisdiction. Following exclusions for insufficient follow-up (< 6 months) and missing data, 162,958 participants were included. Mortality data up to 31 December 2023 were obtained from the National Death Registry of China. Information on eleven system diseases was extracted; three multimorbidity indicators (condition count, multimorbidity patterns, and multimorbidity index) were created. Hazard ratio (HR) with 95% confidence intervals (CI) was calculated using Cox proportional hazard model after adjustment for confounders. The C-statistic, integrated discrimination improvement (IDI), and net reclassification improvement (NRI) were used to compare the performance of multimorbidity indicators.

resultsFifteen thousand five hundred twenty-five deaths were identified during a median of 4.79 years of follow-up. Compared with participants with no multimorbidity, those with multimorbidity had a 1.56-fold risk of all-cause mortality. Every one condition count increment was associated with a 17% increased risk of all-cause mortality. Three multimorbidity patterns labeled as Patterns I, II, and III were extracted and were significantly associated with the increased mortality risk, with HR being 1.97, 1.41, and 1.44 for Patterns I, II, and III respectively. Every 1-unit increment of multimorbidity index was associated with an 18% increased mortality risk. The multimorbidity index demonstrated a slightly better discriminative ability compared to the condition count (IDI: 0.003, NRI: 0.0046) and multimorbidity pattern (IDI: 0.007, NRI: 0.0055).

conclusionsThree multimorbidity indicators were all associated with the increased mortality risk in community-dwelling older Chinese. The multimorbidity index is considered an optimal indicator for predicting mortality risk in community-dwelling older adults. The condition count is also suggested due to its simplicity and superior predictive performance.

Indexed as

MortalityMultimorbidityPopulation SurveillanceAgedAged, 80 and overChinaCohort StudiesEast Asian PeopleFemaleHumansMaleProspective StudiesRisk FactorsCondition countMortalityMultimorbidityMultimorbidity indexMultimorbidity pattern

Identifiers

PMID41654719
PMCPMC13188581

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.