Evidence map›Paper›PMID 41654639›Full record

ArticleJournal of neurology2026

The potential of optical coherence tomography angiography in progressive multiple sclerosis.

Jonathan A Gernert, Hanna Zausinger, Luca Diedrich, Rebecca Wicklein, Linus Kreitner, Tania Kümpfel, Joachim Havla

Abstract read
In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonathan A Gernert *Institute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
Hanna Zausinger *Institute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
Luca DiedrichInstitute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
Rebecca WickleinDepartment of Neurology, TUM University Hospital, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Linus KreitnerChair for AI in Healthcare and Medicine, Technical University of Munich (TUM) and TUM University Hospital, Munich, Germany.
Tania KümpfelInstitute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
Joachim HavlaInstitute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians-Universität München, 81377, Munich, Germany. Joachim.Havla@med.uni-muenchen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early detection and monitoring of neurodegenerative processes in persons with multiple sclerosis (PwMS) is currently a major challenge. Optical coherence tomography angiography (OCTA) is an emerging method to visualize retinal vascular architecture. However, its use has mainly been investigated in relapsing MS. We evaluated OCTA as a possible complementary method in progressive MS (PMS) in a monocentric, retrospective, cross-sectional study. Eyes with evidence of optic neuritis were excluded from analysis. OCTA images acquired using a Spectralis OCT (Heidelberg Engineering) were analyzed with an established deep learning-based segmentation algorithm. After rigorous quality control, 85 eyes of 62 PwPMS were compared with 64 eyes of 43 age and gender-matched healthy controls (HC). The vessel density in the superficial vascular complex (VD

Indexed as

Multiple Sclerosis, Chronic ProgressiveRetinal VesselsTomography, Optical CoherenceAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesOptical coherence tomography angiographyProgressive multiple sclerosisRetinal vasculature

Identifiers

PMID41654639
PMCPMC12882947

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.