Evidence map›Paper›PMID 41654526›Full record

ArticleNPJ Parkinson's disease2026

LRRK2

Shimin Pang, Jing Lu, Yanyan Wang, Chao Ying, Chunsong Zhao, Zhenyu Yue, Qiumei Yang, Piu Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Ex Vivo LRRK2 Activation in Asian G2385R and R1628P Variant Carriers and Idiopathic Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shimin PangDepartment of Neurobiology and National Clinical Research Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
Jing LuDepartment of Neurobiology and National Clinical Research Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
Yanyan WangDepartment of Neurobiology and National Clinical Research Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
Chao YingDepartment of Neurobiology and National Clinical Research Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
Chunsong ZhaoDepartment of Neurobiology and National Clinical Research Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
Zhenyu YueDepartment of Neurobiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Qiumei YangDepartment of Neurobiology and National Clinical Research Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China. qmyang@xwhosp.org.
Piu ChanDepartment of Neurobiology and National Clinical Research Center for Geriatric Disease, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China. pbchan@hotmail.com.

Funding

National Key Research and Development Program of China 2021YFC2501200, 2018YFC1312001National Natural Science Foundation of China 82101657Special Project for Research and Development in Key areas of Guangdong Province 2018B030337001
6 · The paper itself

Abstract

Chronic intestinal inflammation is a key precursor to Parkinson's disease (PD). Leucine-rich repeat kinase 2 R1628P variant (LRRK2

Identifiers

PMID41654526
PMCPMC12996338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.