Evidence map›Paper›PMID 41654504›Full record

ArticleNature communications2026

Adgrg6/Gpr126 is required for compact wall integrity and establishing trabecular identity during cardiac trabeculation.

Swati Srivastava, Felix Gunawan, Silvia Vergarajauregui, Alessandra Gentile, Miriam Angeloni, Sarah C Petersen, Stefan Günther, Fulvia Ferrazzi, Didier Y R Stainier, Felix B Engel

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Adhesion G protein-coupled receptors.Pharmacological reviews · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Swati SrivastavaDepartment of Nephropathology, Institute of Pathology, Experimental Renal and Cardiovascular Research, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.ORCID http://orcid.org/0009-0000-9764-0589
Felix GunawanDevelopmental Genetics, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID http://orcid.org/0000-0002-5592-9680
Silvia VergarajaureguiDepartment of Nephropathology, Institute of Pathology, Experimental Renal and Cardiovascular Research, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.ORCID http://orcid.org/0000-0002-9247-6123
Alessandra GentileDevelopmental Genetics, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID http://orcid.org/0000-0002-5423-7295
Miriam AngeloniInstitute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Sarah C PetersenDepartment of Developmental Biology, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-4540-4909
Stefan GüntherECCPS Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID http://orcid.org/0000-0002-5594-4549
Fulvia FerrazziInstitute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.ORCID http://orcid.org/0000-0003-4011-4638
Didier Y R StainierDevelopmental Genetics, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID http://orcid.org/0000-0002-0382-0026
Felix B EngelDepartment of Nephropathology, Institute of Pathology, Experimental Renal and Cardiovascular Research, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. felix.engel@uk-erlangen.de.ORCID http://orcid.org/0000-0003-2605-3429

Funding

DISSECTING MOLECULAR AND GENETIC MECHANISMS THAT PROMOTE MYELINATIONF32NS087786 · NINDS · WASHINGTON UNIVERSITY · PI PETERSEN, SARAH · 2014 to 2016
$131k
Deutsche Forschungsgemeinschaft (German Research Foundation) EN 453/10-1Deutsche Forschungsgemeinschaft (German Research Foundation) EN 453/10-2Deutsche Forschungsgemeinschaft (German Research Foundation) FOR2149, ProjectDeutsche Forschungsgemeinschaft (German Research Foundation) INST 410/91-1 FUGGDeutsche Forschungsgemeinschaft (German Research Foundation) project number 509149993, TRR 374NINDS NIH HHS F32 NS087786
6 · The paper itself

Abstract

How adhesion G protein-coupled receptors (aGPCRs) control development remains unclear. aGPCR Adgrg6/Gpr126 has been associated with heart trabeculation. Defects in this process cause cardiomyopathies and cardiac dysfunction. How cardiomyocytes attain trabecular identity is poorly understood. Here, we show that different domains of Gpr126 distinctly regulate compact wall integrity and trabecular identity. Maternal zygotic (MZ) gpr126

Indexed as

HeartReceptors, G-Protein-CoupledAnimalsCadherinsCell AdhesionHumansMutationMyocytes, CardiacReceptors, NotchZebrafishCadherinsReceptors, G-Protein-CoupledReceptors, Notch

Identifiers

PMID41654504
PMCPMC12886893

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.