Evidence map›Paper›PMID 41654503›Full record

ArticleScientific data2026

Comprehensive Human Red Blood Cell Membrane and Cytoplasmic Proteome Analyses.

Xue Zhang, Huiru Liu, Qiuhong Zhang, Ting Liu, Shanyu Qi, Liang Wang, Wenjuan Yang, Jiaojiao Sha, Zijin Geng, Liangjia Du and 8 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xue ZhangDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China.
Huiru LiuDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China.
Qiuhong ZhangDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China.
Ting LiuDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China.
Shanyu QiDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China.
Liang WangDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China.
Wenjuan YangDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China.
Jiaojiao ShaDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China.
Zijin GengDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China.
Liangjia DuDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing Normal University, Nanjing, 210008, China.
Qianqian HuDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing Normal University, Nanjing, 210008, China.
Minqi CaiDepartment of Nuclear Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
Dezhu ChenDepartment of Nuclear Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
Yiqiang ChenCenter for Precision Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
Siyuan LiuCenter for Precision Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
Hongyan SongDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
Jie PanDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
Bing BaiDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China. bing.bai@nju.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82472333
6 · The paper itself

Abstract

Red blood cells (RBCs) are essential to human and involved in many clinical disorders. Many proteomics studies have been done on human RBCs, but the coverages are insufficient, limiting full understanding of protein profiles in RBCs and the mechanisms of their involved diseases. With major advances now available in the mass spectrometry-based proteomics filed, here we have isolated human RBCs into the membrane and cytoplasmic fractions and performed extensive offline basic pH RPLC fractionation followed by proteomic analyses. This in-depth proteomics approach has identified 4777 proteins in the RBC membrane fraction and 2350 proteins in the cytoplasmic fraction, yielding 5264 proteins in total which is probably the largest human RBC proteomics scale in the field. Such comprehensive RBC proteome datasets provide valuable data resource for elucidation of human RBCs and their involved diseases.

Indexed as

CytoplasmErythrocyte MembraneErythrocytesProteomeHumansProteomicsProteome

Identifiers

PMID41654503
PMCPMC12992542

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.