ArticleBrain stimulation
A nonlinear relationship of evoked responses following charge-balanced single-pulse electrical stimulation with varying pulse widths.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Conserved fiber topography of the anterior limb of the internal capsule in treatment-resistant psychiatric patients.bioRxiv : the preprint server for biology · 2026Article
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14 authors.
Funding
Abstract
backgroundSingle-pulse electrical stimulation (SPES) can help guide neuromodulation therapy in an iterative process to reveal ideal circuits and degrees of engagement. Understanding the relationship between parameter input and neural output will be necessary both to build informative models of the brain's functional connectivity and to improve responses to stimulation-based neuromodulation therapies. Modulating pulse width alters the total charge delivered to neural tissue and is thought to selectively activate fibers with different diameters, potentially shifting therapeutic thresholds. The anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC) are of great clinical relevance to the pathophysiology and treatment of neuropsychiatric disorders.
objectiveTo provide empirical evidence for the impact of pulse width on pulse-evoked responses and promote the ability to modify specific circuits.
methodsWe measured evoked response robustness, peak amplitude, and latency to peak amplitude from depth electrode contacts in 20 epilepsy patients undergoing intracranial monitoring for treatment-refractory epilepsy.
resultsA nonlinear relationship between pulse width with evoked potential robustness was determined. Pulse width modulation is further shown to be distance-dependent, with distant connections responding maximally to a shorter pulse width.
conclusionThese results emphasize the importance of input stimulation parameters on cerebro-cerebral evoked potential (CCEP) response magnitude and consistency and are a step towards guiding selective engagement of specific fiber populations for both research and clinical settings.
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