More insights from Abca4

Jin Zhao, Diego Montenegro, Sihua Cheng, Hye Jin Kim, Janet R Sparrow

Abstract read

In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Loss of ABCA4 from photoreceptor discs is associated with glial transcriptomic changes in retinal organoids.Stem cells (Dayton, Ohio) · 2026
Article
Beneficial Effects of Natural Bioactive Compounds on Eye Health: A Narrative Review.International journal of molecular sciences · 2026
Review
Abca4 Knockdown in the Cone-Rich Rodent Psammomys Obesus Leads to Stargardt's Disease-Like Progressive Retinal Degeneration.Investigative ophthalmology & visual science · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jin ZhaoDepartment of Ophthalmology, Columbia University Medical Center, New York, New York, USA.

Diego MontenegroDepartment of Ophthalmology, Columbia University Medical Center, New York, New York, USA.

Sihua ChengDepartment of Ophthalmology, Columbia University Medical Center, New York, New York, USA.

Hye Jin KimDepartment of Ophthalmology, Columbia University Medical Center, New York, New York, USA.

Janet R SparrowDepartment of Ophthalmology, Columbia University Medical Center, New York, New York, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, USA. Electronic address: jrs88@columbia.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the ABC transporter ABCA4 (ABC, subfamily A, member 4) are responsible for recessive Stargardt disease 1 (STGD1), a juvenile form of macular degeneration. In preclinical and clinical studies, it has been shown that deficiency in ABCA4 leads to accelerated formation of the toxic bisretinoid fluorophores that form as the product of nonenzymatic reactions of retinaldehyde with phosphatidylethanolamine (2:1 ratio). Here, by comparing photoreceptor cell viability in albino versus agouti Abca4

Indexed as

ATP Binding Cassette Transporter, Subfamily A, Member 4Stargardt DiseaseAnimalsATP-Binding Cassette TransportersDisease Models, AnimalMiceMice, KnockoutRetinoidsAbca4 protein, mouseATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily A, Member 4RetinoidsABC transporterphotoreceptorretinaretinal degenerationretinoid

Identifiers

PMID41654128

DOI10.1016/j.jbc.2026.111261

PMCPMC12961320

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.