ArticleMolecular cell2026
Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders.
Abstract read
In one paragraph
Article in Molecular cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Polycomb Group Proteins inBiology · 2026Review
- From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.Trends in neurosciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Rodrigo L BorgesSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Gretter González-BlancoSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Harikumar ArigelaSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Yingyu HuangSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Lucas D CaeiroSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Division of Hematology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Nikolai FattakhovSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Stefano LeporeSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Liliana Garcia-MartinezSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Matea MauriceDepartment of Cell & Systems Biology, University of Toronto, Toronto, ON, Canada.
Pushti D MehtaSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Emily J ParkStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Department of Molecular and Cellular Biology Houston, Houston, TX 77030, USA.
Kailynn MacGillivrayDepartment of Cell & Systems Biology, University of Toronto, Toronto, ON, Canada.
Jevithen NehruDepartment of Cell & Systems Biology, University of Toronto, Toronto, ON, Canada.
Matthew ChauDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Baylor Genetics, Houston, TX 77021, USA.
Maria C RobayoDepartment of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Clemer AbadDepartment of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Alicia Bilbao-MartinezSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Fabiola MonteiroMendelics, São Paulo, Brazil.
Xi LuoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Baylor Genetics, Houston, TX 77021, USA.
Song TanCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Daniel BilbaoSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Simone SidoliDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bruno Di StefanoStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Department of Molecular and Cellular Biology Houston, Houston, TX 77030, USA.
Katherina WalzDepartment of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Departamento de Ingeniería Biomédica, Facultad de Ingeniería, Universidad Austral, CONICET, Buenos Aires 1428, Argentina.
Arneet L SaltzmanStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Department of Molecular and Cellular Biology Houston, Houston, TX 77030, USA.
Ramiro E VerdunSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Division of Hematology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Geriatric Research, Education, and Clinical Center, Miami VA Healthcare System, Miami, FL 33136, USA.
Ramin ShiekhattarSylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Lluis MoreySylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: lmorey@med.miami.edu.
Funding
Altering the chromostasis and genome stability by modulating histone methylationR01GM146409 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MOREY, LLUIS, VERDUN, RAMIRO ERNESTO · 2022 to 2025
$1.7MMechanisms of RING1B and PRC1 complexes in transcriptional activationR01GM141349 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Lluis Morey · 2022 to 2026
$1.6MDefining the role of ILF2-ILF3 in human cell fateF30HD114315 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Emily J Park · 2024 to 2026
$157kNICHD NIH HHS F30 HD114315NIGMS NIH HHS R01 GM141349NIGMS NIH HHS R01 GM146409
Abstract
The prevalence of neurodevelopmental disorders (NDDs) in children is increasing, yet their underlying causes remain largely unknown. We identified heterozygous mutations in the Polycomb repressive complex 1 (PRC1) E3 ligases RING1 and RNF2 in individuals with NDDs and revealed distinct mechanisms by which they compromise PRC1 activity. We developed cellular and mouse models carrying the Ring1b
Indexed as
ChromatinNeurodevelopmental DisordersPolycomb-Group ProteinsPolycomb Repressive Complex 1Polycomb Repressive Complex 2Ubiquitin-Protein LigasesAnimalsDisease Models, AnimalEpigenesis, GeneticFemaleHippocampusHumansMaleMiceMutationNeurogenesisChromatinPolycomb-Group ProteinsPolycomb Repressive Complex 1Polycomb Repressive Complex 2Ring1 protein, mouseRNF2 protein, humanRnf2 protein, mouseUbiquitin-Protein Ligasesepigeneticsgenetic variantsneurodevelopmental disordersneurogenesisPolycombstem cells
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.