ReviewMolecular cell2026
Density transitions in the regulation of transcription.
Review in Molecular cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Step-brothers in arms, SAGA and ATAC co-activator complexes, use different strategies.The EMBO journal · 2026Review
- Disease-Associated Mutations Impact DNA Methyltransferase 1 Function through Dynamic Allosteric Effects and Solvent Exposure.Journal of chemical theory and computation · 2026Article
- Review
- Beyond the canonical view: steroid receptor network plasticity and mechanosensitive chromatin integration in breast cancer.NAR cancer · 2026Review
- Transcriptional Bursting in Pluripotent Stem Cells.Biology · 2026Review
- Simulation of transcription factor clustering in nuclei from molecular kinetics.bioRxiv : the preprint server for biology · 2026Article
- Nup42 safeguards heat-induced mRNAs from nuclear condensation to support chaperone synthesis.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Transcription of the right genes at the right time is crucial for physiology and often dysregulated in disease. For a process that requires precise outcomes, the underlying molecular interactions regulating transcription can be surprisingly dynamic and short-lived. Various sources of multivalency have been proposed to stabilize short-lived interactions at specific genomic loci. Through multivalent contacts, components of the transcription machinery form complexes and, above-threshold concentrations, can form condensates by undergoing reversible density transitions (i.e., phase separation). Importantly, coupling the density transition to networking generates a condensate-spanning network with emergent properties that soluble complexes do not possess, including enhanced dwell times of relevant components, distinct chemical environments, capillary forces, and biochemically active interfaces. Here, we will review the current evidence for and against the role of density transitions in regulating transcription, discuss best practices for studying the functional roles of these phenomena, and consider how emergent properties may regulate transcription.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.