Evidence map›Paper›PMID 41653918›Full record

ArticleMolecular cell2026

Molecular basis for anti-jumbo phage immunity by AVAST type 5.

Aswin Muralidharan, Ana Rita Costa, Desi Fierlier, Daan Frits van den Berg, Halewijn van den Bossche, Adja Damba Zoumaro-Djayoon, Alicia Rodríguez-Molina, Martin Pabst, Martin Pacesa, Bruno E Correia and 1 more

Abstract read
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In one paragraph

Article in Molecular cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Article
  4. The biology of jumbo phages.Nature communications · 2026
    Review
  5. Article
  6. A methylome-derived mbioRxiv : the preprint server for biology · 2026
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aswin MuralidharanDepartment of Bionanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands; Kavli Institute of Nanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands.
Ana Rita CostaDepartment of Bionanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands; Kavli Institute of Nanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands.
Desi FierlierDepartment of Bionanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands; Kavli Institute of Nanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands.
Daan Frits van den BergDepartment of Bionanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands; Kavli Institute of Nanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands.
Halewijn van den BosscheDepartment of Bionanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands; Kavli Institute of Nanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands.
Adja Damba Zoumaro-DjayoonDepartment of Bionanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands; Kavli Institute of Nanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands.
Alicia Rodríguez-MolinaDepartment of Bionanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands; Kavli Institute of Nanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands.
Martin PabstDepartment of Biotechnology, Delft University of Technology, 2629 HZ Delft, the Netherlands.
Martin PacesaLaboratory of Protein Design and Immunoengineering, École Polytechnique Fédérale de Lausanne and Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Bruno E CorreiaLaboratory of Protein Design and Immunoengineering, École Polytechnique Fédérale de Lausanne and Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Stan J J BrounsDepartment of Bionanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands; Kavli Institute of Nanoscience, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, the Netherlands. Electronic address: stanbrouns@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Jumbo phages protect their genomes from DNA-sensing bacterial defense systems by enclosing them within vesicles and nucleus-like compartments. Very little is known about defense systems specialized to counter these phages. Here, we show that AVAST type 5 (Avs5) systems, part of the signal transduction ATPases of numerous domains (STAND) superfamily, confer conserved immunity against jumbo phages. Using fluorescence microscopy and biotin proximity labeling, we demonstrate that Avs5 localizes to early infection vesicles, where it senses an essential, early-expressed phage protein named JADA (Jumbo phage Avs5 Defense Activator). Recognition of phage infection triggers the Sir2-like effector domain of Avs5 across three Avs5 clades, resulting in rapid NAD

Indexed as

Adenosine TriphosphatasesBacterial ProteinsPseudomonas PhagesViral ProteinsHost-Pathogen InteractionsInnate Immunity RecognitionNADSignal TransductionAdenosine TriphosphatasesBacterial ProteinsNADViral Proteinsanti-jumbo phage immunityAVASTdefense systemsEPI vesiclejumbo phagePseudomonas aeruginosaSir2STANDTurboID

Identifiers

PMID41653918
PMCPMC12931631

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.