Evidence map›Paper›PMID 41653640›Full record

ArticleNeurobiology of aging2026

Quantifying calretinin-labeled afferent terminals in vestibular sensory epithelia of young and older gerbils.

Anna Dondzillo, Tyler Bauer, Kathryn King, Anthony Peng, Katherine J Rennie

Abstract read
In one paragraph

Article in Neurobiology of aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna DondzilloDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO, United States.
Tyler BauerDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO, United States.
Kathryn KingDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO, United States.
Anthony PengDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO, United States.
Katherine J RennieDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO, United States. Electronic address: Katie.rennie@cuanschutz.edu.

Funding

University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
ZEBRAFISH TRANSGENIC CORE - ROCKY MOUNTAIN NEUROLOGICAL DISORDERS CORE CENTERP30NS048154 · NINDS · UNIVERSITY OF COLORADO DENVER · PI RIBERA, ANGELES BADELL · 2004 to 2020
$10.1M
Aging and Dysfunction in the Peripheral Vestibular SystemR01AG073997 · NIA · UNIVERSITY OF COLORADO DENVER · PI PENG, ANTHONY WEI, RENNIE, KATHERINE JANET · 2021 to 2025
$3.1M
Ion Channels and Excitability in the Peripheral Vestibular SystemR01DC018786 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI RENNIE, KATHERINE JANET · 2021 to 2025
$1.9M
NIA NIH HHS R01 AG073997NIDCD NIH HHS R01 DC018786NIDDK NIH HHS P30 DK116073NINDS NIH HHS P30 NS048154
6 · The paper itself

Abstract

Vestibular dysfunction becomes increasingly prevalent with aging and it is estimated that more than 80 % of people over 80 years old experience balance problems linked to vestibular dysfunction. Within the peripheral vestibular organs, sensory hair cells transform hair bundle motion into receptor potentials and information is next relayed to the brain by electrical activity in vestibular afferent nerves. There are three types of vestibular afferents: calyx-only afferents innervate one or more type I hair cells; bouton dendrites innervate type II hair cells and dimorphic afferents contact both hair cell types. Calyx-only afferents are found solely in central areas of vestibular neuroepithelia and have distinct physiological characteristics. Previous studies have shown changes in vestibular-mediated responses with aging in addition to age-related degeneration of afferent synapses in rodent inner ear epithelia. However, whether calyx-only afferent synapses are lost with aging in vestibular epithelia remains unresolved. Here we used an antibody to the Ca

Indexed as

AgingCalbindin 2Neurons, AfferentVestibule, LabyrinthAnimalsGerbillinaeHair Cells, VestibularMaleCalbindin 2AgingCalretininCalyx-only terminalsCristaStriolaUtricle

Identifiers

PMID41653640
PMCPMC13540381

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.