The impact of Spirulina platensis supplementation on performance and immune response in laying hens.

Mohammed Al-Rasheed, Mohamed Shawky El Sayed, Khaled M A Ramadan, Eslam S A Bendary, Sherief Mohmaed Abdel-Raheem

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Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Mohammed Al-RasheedDepartment of Clinical Sciences, College of Veterinary Medicine, King Faisal University, P.O. Box 400, Al-Hofuf, 31982, Al-Ahsa, Saudi Arabia. malrasheed@kfu.edu.sa.

Mohamed Shawky El SayedAvian Research Center, King Faisal University, P.O. Box 400, Al-Hofuf, 31982, Al-Ahsa, Saudi Arabia.

Khaled M A RamadanDepartment of Chemistry, Central Laboratories, King Faisal University, P.O. Box 400, Al- Hofuf, 31982, Al-Ahsa, Saudi Arabia.

Eslam S A BendaryDepartment of Biochemistry, Faculty of Agriculture, Ain Shams University, Cairo, 11241, Egypt.

Sherief Mohmaed Abdel-RaheemDepartment of Public Health, College of Veterinary Medicine, King Faisal University, P.O. Box 400 , Al-Hofuf, 31982, Al-Ahsa, Saudi Arabia.

Funding

Deanship of Scientific Research, King Faisal University KFU252981

6 · The paper itself

Abstract

This study evaluated the effects of dietary supplementation with different levels of Spirulina platensis (SP) on laying performance, immune response, serum fatty acid profile of laying hens and SP's in vitro antioxidant capacity. About 160 hens were assigned to four dietary treatments: control (0) and SP-supplemented diets (1.5, 3, and 4.5 g/kg diet). Supplementation with SP showed notable, significant positive effects on laying rate (92.9-94.5%), egg weight (62.2-67.1 g), egg mass, yolk color, shell quality traits, and feed conversion ratio compared to the control group (P < 0.05). SP supplementation also enhanced the humoral immune response, as shown by increased Newcastle disease antibody titers, particularly at 1.5 and 3 g/kg during the first 60 days. Gas Chromatography-Mass Spectrometry (GC-MS) analysis of serum fatty acid profile revealed a dose- and time-dependent increase in beneficial unsaturated fatty acids and a marked reduction in cholesterol levels in SP-fed hens. In vitro evaluations showed that SP extract had potent antioxidant activity with 2, 2-azino-bis-3 ethylbenzothiazoline-6-sulfonic acid (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity comparable to vitamins C and E, particularly at high concentrations (3 and 4.5 g/kg). These results highlight the promising potential of Spirulina platensis as a functional, natural feed additive to improve the laying performance, egg quality, immune response, yolk fat and provide potent antioxidant protection in poultry production systems.

Indexed as

ChickensDietary SupplementsSpirulinaAnimal FeedAnimalsAntioxidantsDietFatty AcidsFemaleImmunity, HumoralAntioxidantsFatty AcidsAntioxidant activityFatty acid profileFeed additivesImmune responseLaying hensSpirulina platensis

Identifiers

PMID41653387

DOI10.1007/s00204-016-1744-5

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.