Evidence map›Paper›PMID 41653369›Full record

ArticleBiogerontology2026

Antioxidant and anti-aging activities of Salvia miltiorrhiza Bunge callus extracts in H

Shinn-Zong Lin, Tzu-Kai Lin, Wei-Wen Kuo, Shih-Wen Kao, Chia-Hua Kuo, Dennis Jine-Yuan Hsieh, Yueh-Min Lin, Tsung-Jung Ho, Shang-Chuan Ng, Chih-Yang Huang

Abstract read
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In one paragraph

Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shinn-Zong LinBioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Tzu-Kai LinDepartment of Dermatology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Wei-Wen KuoDepartment of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Shih-Wen KaoDepartment of Orthopedic Surgery, Chung-Shan Medical University Hospital, Taichung, Taiwan.
Chia-Hua KuoLaboratory of Exercise Biochemistry, Department of Health and Physical Education, The Education University of Hong Kong, Hong Kong SAR, China.
Dennis Jine-Yuan HsiehDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
Yueh-Min LinDepartment of Pathology, Changhua Christian Hospital, Changhua, Taiwan.
Tsung-Jung HoDepartment of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Shang-Chuan Ng *Department of Biological Science and Technology, China Medical University, Taichung, Taiwan. shangchuan_622@hotmail.com.
Chih-Yang Huang *Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. cyhuang@mail.cmu.edu.tw.

Funding

Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation IMAR-114-01-02National Science and Technology Council, Taiwan NSTC-114-2320-B-303-003-MY3
6 · The paper itself

Abstract

Dermal fibroblasts are pivotal in maintaining skin integrity through extracellular matrix (ECM) production, a process compromised during aging due to oxidative stress from excessive reactive oxygen species (ROS). Salvia miltiorrhiza Bunge (Danshen, DS), a medicinal plant rich in bioactive compound-rich dried roots, has demonstrated broad therapeutic potential. This study investigates the anti-aging properties of Danshen callus (DSC)-an undifferentiated cell mass derived from leaf tissue culture, as a sustainable and controlled source of bioactive compounds. Using hydrogen peroxide (H

Indexed as

Aging, PrematureAntioxidantsCellular SenescenceFibroblastsPlant ExtractsSalvia miltiorrhizaCells, CulturedHumansHydrogen PeroxideOxidative StressReactive Oxygen SpeciesAntioxidantsHydrogen PeroxidePlant ExtractsReactive Oxygen SpeciesChronological agingDanshen callus (DSC)Human dermal fibroblast (HDFs)Premature aging

Identifiers

PMID41653369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.