ArticleMolecular biology reports2026
Immunomodulatory effects of platelet-rich plasma on inflammatory and metabolic responses of B92 glial cells exposed to heat-killed Escherichia coli.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelets and platelet-derived factors are increasingly recognised as modulators of immune and inflammatory processes beyond haemostasis. However, their effects on astrocyte-like glial cells under basal and infection-mimicking conditions remain incompletely characterised in vitro. METHODS AND
resultsIn this study, B92 glial cells were exposed to platelet-rich plasma (PRP; 0–20%) under basal conditions or in the presence of heat-killed Escherichia coli (HKEC) as an infection-mimicking inflammatory stimulus. After 24 h of treatment, cellular metabolic activity (MTT), lysosomal/endocytic activity (neutral red uptake), oxidative stress (NBT reduction), and transcriptional expression of selected cytokines (TNF-α, IL-10, IL-1β) and apoptosis-related genes (BAX, Caspase-3, BCL-2) were assessed. PRP induced dose-dependent changes in metabolic activity and oxidative stress markers under both experimental conditions. At the transcriptional level, PRP exposure was associated with reduced TNF-α and increased IL-10 expression, while IL-1β expression showed limited attenuation, particularly under HKEC stimulation, indicating a mixed and context-dependent immunomodulatory profile. PRP treatment was also associated with altered expression of apoptosis-related genes, characterised by increased BCL-2 and reduced BAX and Caspase-3 mRNA levels, without direct functional validation of apoptotic outcomes.
conclusionsThese findings demonstrate that PRP modulates metabolic activity, oxidative stress, and inflammatory gene expression in B92 glial cells under basal and infection-mimicking conditions in vitro. The results support a context-dependent immunomodulatory effect of PRP-derived factors at the transcriptional and functional assay level. Given the exclusive use of an immortalised glial cell line and the absence of platelet-specific and functional apoptosis controls, the findings should be interpreted as descriptive and hypothesis-generating, warranting further mechanistic and in vivo investigation.
Indexed as
Identifiers
41653347What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.