Evidence map›Paper›PMID 41653294›Full record

ReviewJournal of neural transmission (Vienna, Austria : 1996)2026

Unraveling mGluR5 dysfunction in autism spectrum disorder: a multi-level analysis of genetic, molecular, and neurobiological mechanisms.

Arpan Dhungel, Rinchi Bora

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Arpan DhungelFaculty of Pharmaceutical Science, Assam down town University, Panikhaiti, Guwahati, Assam, 781026, India.ORCID http://orcid.org/0009-0000-0689-076X
Rinchi BoraFaculty of Pharmaceutical Science, Assam down town University, Panikhaiti, Guwahati, Assam, 781026, India. rinchi.b@adtu.in.ORCID http://orcid.org/0000-0002-0140-4125

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review summarizes the current evidence regarding the role of metabotropic glutamate receptor 5 (mGluR5) in autism spectrum disorder (ASD) integrating genetic, molecular, neuroimaging, and therapeutic evidence to evaluate the mGluR5 related pathways in ASD mechanisms and evaluate its potential as a therapeutic target. RECENT

findingsGenetic studies report 25-fold peripheral GRM5 downregulation in ASD patients, with specific variants (rs905646, rs762724) showing biased paternal transmission and associations with increased symptom severity. Advances in super resolution imaging demonstrate that mGluR5 is confined to perisynaptic nanodomains with restricted lateral mobility, forming localized signaling microdomains critical for synaptic modulation. First in-human positron emission tomography (PET) studies using [

Indexed as

Autism spectrum disorderExcitatory/inhibitory imbalanceMetabotropic glutamate receptor 5Neurological disorderSHANK3Synaptic plasticity

Identifiers

PMID41653294

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.