Evidence map›Paper›PMID 41653196›Full record

ArticleMikrochimica acta2026

Dual-mode photothermal and colorimetric immunosensor based on polydopamine@Prussian blue nanocomposite for sensitive detection of benzocaine.

Bao-Zhu Jia, Wen-Feng Zhang, Qing-Chun Yin, Xue-Ying Rui, Lin Luo, Zhen-Lin Xu

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bao-Zhu JiaCollege of Biology and Food Engineering, Guangdong University of Education, Guangzhou, 510303, China.
Wen-Feng ZhangGuangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology, Guangdong Provincial Engineering Research Center of Rapid Testing Instrument for Food Nutrition and Safety, Institute of Analysis, Guangdong Academy of Sciences (China National Analytical Center, Guangzhou), Guangzhou, 510070, China.
Qing-Chun YinKey Laboratory of Tropical Fruits and Vegetables Quality and Safety for State Market Regulation, Hainan Institute for Food Control, Haikou, 570314, China.
Xue-Ying RuiGuangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China.
Lin LuoGuangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China. lin.luo@scau.edu.cn.
Zhen-Lin XuGuangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China.

Funding

Guangdong Basic and Applied Basic Research Foundation 2023A1515030011
6 · The paper itself

Abstract

A dual-mode immunosensor based on polydopamine@Prussian blue nanoparticles (PDA@PB NPs) was developed for rapid and sensitive detection of benzocaine (BZC) in aquatic food. PDA@PB NPs possess excellent peroxidase-like activity, photothermal conversion efficiency, and antibody-binding capacity, enabling simple, crosslinker-free antibody immobilization. Upon target recognition, the sensor produces a distinct blue color via TMB–H2O2 oxidation and a robust near-infrared photothermal signal, allowing dual-mode quantitative determination. Under optimized conditions, the sensor showed a linear range of 0.01–1000 ng/mL, with detection limits of 0.33 ng/mL (colorimetric) and 0.82 ng/mL (photothermal). The integration of colorimetric and photothermal outputs improves detection accuracy, reduces matrix interference, and eliminates the need for complex instrumentation. Validation with spiked real samples confirmed its reliability and applicability. This portable, cost-effective immunosensor offers a promising tool for on-site monitoring of BZC residues in aquatic products, contributing to enhanced food safety surveillance.

Indexed as

BenzocaineColorimetryFerrocyanidesIndolesNanocompositesPolymersAnimalsAntibodies, ImmobilizedFood ContaminationImmunoassayLimit of DetectionAntibodies, ImmobilizedBenzocaineferric ferrocyanideFerrocyanidesIndolespolydopaminePolymersBenzocaineColorimetric immunoassayDual-mode assayNanozymePhotothermal immunoassayPolydopaminePrussian blue

Identifiers

PMID41653196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.