ArticleMolecular pharmaceutics2026
Microstructural Insights into Solid Dispersions: A Combined Small-Angle Neutron Scattering and Molecular Dynamics Approach.
Article in Molecular pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Solid dispersion is a widely adopted formulation strategy to enhance the solubility of water-insoluble drugs. However, the molecular-level structural determinants of stability and dissolution behavior remain poorly understood. This study integrates Small-Angle Neutron Scattering (SANS) technology with coarse-grained molecular dynamics (CGMD) simulations to investigate the effects of preparation methods (melting vs solvent evaporation) and drug loadings (10%, 15%, 25%) on the microstructure and crystallinity of PXM-PEG solid dispersions. Deuterated PEG (d-PEG) is used in the SANS to enhance the scattering intensity in samples. The findings revealed that the lamellar thickness decreased significantly from 173.01 Å (pure d-PEG) to 44.12 Å (25% drug loading, melting method), while the
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