Evidence map›Paper›PMID 41653125›Full record

ArticleJournal of medicinal chemistry2026

Rediscovering Diazaborines: Synthesis and Bioactivity Profiling of Boron-Containing FabI Inhibitors against Gram-Negative Bacteria.

Polina Ilina, Vladimir Iashin, Cristina D Cruz, Juho Heininen, Iiro Järvi, Inna Pönniö, Sami Heikkinen, Pauli Johan Wrigstedt, Leo Ghemtio, Karina Moslova and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Polina IlinaDrug Research Program, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki FI-00014, Finland.ORCID 0000-0002-6705-6338
Vladimir IashinDepartment of Chemistry, Faculty of Science, University of Helsinki, P.O. Box 55, FI-00014, Helsinki, Finland.
Cristina D CruzDrug Research Program, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki FI-00014, Finland.ORCID 0000-0003-4655-8563
Juho HeininenDrug Research Program, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki FI-00014, Finland.ORCID 0000-0002-4879-8643
Iiro JärviDrug Research Program, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki FI-00014, Finland.
Inna PönniöDrug Research Program, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki FI-00014, Finland.
Sami HeikkinenDepartment of Chemistry, Faculty of Science, University of Helsinki, P.O. Box 55, FI-00014, Helsinki, Finland.ORCID 0000-0002-1892-8574
Pauli Johan WrigstedtDepartment of Chemistry, Faculty of Science, University of Helsinki, P.O. Box 55, FI-00014, Helsinki, Finland.ORCID 0000-0003-4083-6059
Leo GhemtioDrug Research Program, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki FI-00014, Finland.ORCID 0000-0003-3591-5676
Karina MoslovaDepartment of Chemistry, Faculty of Science, University of Helsinki, P.O. Box 55, FI-00014, Helsinki, Finland.
Henri XhaardDrug Research Program, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki FI-00014, Finland.ORCID 0000-0002-3000-7858
Paula KiuruDrug Research Program, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki FI-00014, Finland.ORCID 0000-0001-6084-684X
Jesús Perea-BucetaDepartment of Chemistry, Faculty of Science, University of Helsinki, P.O. Box 55, FI-00014, Helsinki, Finland.
Päivi TammelaDrug Research Program, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki FI-00014, Finland.ORCID 0000-0003-4697-8066

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we investigated the potential of diazaborine compounds for antibacterial drug development. Most promising diazaborines demonstrated activity against several Gram-negative pathogens including

Identifiers

PMID41653125
PMCPMC12951463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.