Evidence map›Paper›PMID 41652975›Full record

ReviewPharmacogenomics

Importance of genetic ancestry in pharmacogenomics for precision medicine.

Rasika Venkatesh, Karl Keat, Maxwell Salvatore, Zinhle Cindi, Molly A Hall, Marylyn D Ritchie

Abstract readReview
In one paragraph

Review in Pharmacogenomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rasika VenkateshDepartment of Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Karl KeatDepartment of Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Maxwell SalvatoreDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.
Zinhle CindiDepartment of Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Molly A HallDepartment of Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Marylyn D RitchieDepartment of Genetics, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1208-1720

Funding

Pharmacogenomics of HIV TherapyR01AI077505 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAAS, DAVID W · 2008 to 2025
$12.3M
Clinical Implementation Resources for Pharmacogenomics (CIRP)U24HG013077 · NHGRI · STANFORD UNIVERSITY · PI CAUDLE, KELLY E., KLEIN, TERI ELLEN · 2023 to 2025
$4.4M
Augmenting Pharmacogenetics with Multi-Omics Data and Techniques to Predict Adverse Drug Reactions to NSAIDsF31HG013246 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI KEAT, KARL ERNST · 2023 to 2025
$97k
NHGRI NIH HHS F31 HG013246NHGRI NIH HHS U24 HG013077NIAID NIH HHS R01 AI077505
6 · The paper itself

Abstract

Genetic ancestry refers to an individual's biogeographical origins inferred from correlated allele frequencies shared with individuals from similar ancestral regions. Understanding the complexities of genetic ancestry has proven beneficial in the field of pharmacogenomics (PGx), where personalized medication regimens are optimizing therapeutic outcomes while minimizing the risk of side effects. With the rise in the availability of electronic health records (EHR), population-specific genetic data can be integrated with clinical data using machine learning approaches to improve personalized treatment plans. Furthermore, multiomics data such as the transcriptome, methylome, proteome, and metabolome, paired with advances in machine learning methods, provide a more comprehensive approach to understanding genetic variation. The expansion of PGx studies in diverse populations can broaden the impact of precision medicine, particularly among underrepresented groups.

Indexed as

PharmacogeneticsPrecision MedicineElectronic Health RecordsGene FrequencyGenetic VariationHumansMachine LearningMultiomicsartificial intelligencebiobank datagenetic ancestrymulti-omicsPharmacogenomicspolygenic scoresprecision medicine

Identifiers

PMID41652975
PMCPMC12915776

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.