Evidence map›Paper›PMID 41652862›Full record

Trial reportAustralian endodontic journal : the journal of the Australian Society of Endodontology Inc2026

Effect of Simvastatin on Success of Pulpotomy in Carious Permanent Molars With Symptomatic Irreversible Pulpitis: A Randomised Controlled Trial.

Sudeepender Gehlot, Vinay Kumar, Shweta Mittal, Jigyasa Duhan, Pankaj Sangwan, Mayank Arora, Nishant Chauhan

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Australian endodontic journal : the journal of the Australian Society of Endodontology Inc, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04374214 (Effect of Simvastatin on Success of Pulpotomy in Cariously Exposed Permanent Molars), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04374214 naunknown statusnot on this map

Effect of Simvastatin on Success of Pulpotomy in Cariously Exposed Permanent Molars: a Randomized Control Trial

TypeinterventionalSponsorPostgraduate Institute of Dental Sciences RohtakRan2018 to 2020Enrolled56ConditionsReversible PulpitisArmsComplete Pulpotomy using Mineral Trioxide Aggregate, Complete Pulpotomy using Simvastain -alphatricalcium phosphate
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sudeepender GehlotDepartment of Conservative Dentistry and Endodontics, PGIDS, Rohtak, India.
Vinay KumarDepartment of Conservative Dentistry and Endodontics, PGIDS, Rohtak, India.ORCID https://orcid.org/0009-0008-0693-2155
Shweta MittalDepartment of Conservative Dentistry and Endodontics, PGIDS, Rohtak, India.ORCID https://orcid.org/0000-0002-7923-9860
Jigyasa DuhanDepartment of Conservative Dentistry and Endodontics, PGIDS, Rohtak, India.
Pankaj SangwanDepartment of Conservative Dentistry and Endodontics, PGIDS, Rohtak, India.ORCID https://orcid.org/0000-0003-1851-8978
Mayank AroraDepartment of Conservative Dentistry and Endodontics, PGIDS, Rohtak, India.
Nishant ChauhanDepartment of Conservative Dentistry and Endodontics, PGIDS, Rohtak, India.ORCID https://orcid.org/0000-0002-8242-6667

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to assess the effectiveness of simvastatin (SMV) in combination with alpha tricalcium phosphate (αTCP) as pulpotomy agents in cariously exposed permanent mandibular molars with symptomatic irreversible pulpitis. Sixty patients were randomly assigned equally to either the SMV-αTCP or MTA group. The overall success of the treatments was evaluated after 12 months. Pain levels were recorded by patients preoperatively and postoperatively at intervals of 6, 12, 18 h and days 1 through 7. No significant difference in success rates was found between the SMV-αTCP (92.5%) and MTA (96.2%) groups (p > 0.05). Although a significant difference in pain intensity was noted between the groups on the first and second days (p < 0.05), no significant differences in pain levels were observed at any other time points. The outcomes of this study suggest that SMV can be effectively utilised as a pulpotomy agent in carious permanent teeth. Trial Registration: ClinicalTrials.gov identifier: NCT04374214.

Indexed as

Dental CariesMolarPulp Capping and Pulpectomy AgentsPulpitisPulpotomySimvastatinAdolescentAdultAluminum CompoundsCalcium CompoundsDrug CombinationsFemaleFollow-Up StudiesHumansMaleOxidesAluminum CompoundsCalcium CompoundsDrug Combinationsmineral trioxide aggregateOxidesPulp Capping and Pulpectomy AgentsSilicatesSimvastatinalpha tricalcium phosphatemineral trioxide aggregatepulpotomysimvastatinvital pulp therapy

Identifiers

PMID41652862
PMCPMC13436228

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.